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Doxycycline is authorised in the world under the following brand names: Alti-Doxycycline, Apo-Doxy, Atridox, Doryx, Doxy 100, Doxy-Caps, Doxy-Lemmon, Doxychel, Doxychel Hyclate, Doxycin, Doxylin, Doxytec, Jenacyclin, Monodox, Novo-Doxylin, Nu-Doxycycline, Oracea, Periostat, Supracyclin, Vibra-Tabs, Vibramycin.

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Cholera

An acute infectious disease caused by Vibrio cholerae (El Tor type is responsible for current epidemic, the other type, classic, is found only in Bangladesh). (New serotype now in Bangladesh, India (0139). Important because of lack of efficacy of standard vaccine.) Characteristics include severe diarrhea with extreme fluid and electrolyte depletion, and vomiting, muscle cramps and prostration.

Cervicitis

Infectious cervicitis may be caused by Chlamydia trachomatis, Neisseria gonorrhoeae, Mycoplasma genitalium, ureaplasmas, Herpes simplex or Trichomonas vaginalis. Chronic cervicitis is characterized by inflammation of the cervix without an identified pathogen.

Babesiosis

Several other drugs have been evaluated, including tetracycline, primaquine, sulfadiazine (Microsulfon) and pyrimethamine (Fansidar). Results have varied. Pentamidine (Pentam) has proved to be moderately effective in diminishing symptoms and decreasing parasitemia. Others: High-level parasitemia is more common in asplenic patients.

Specific Anti-Infective Agents

Clinicians should be familiar with the general classes of antibiotics, their mechanisms of action, and their major toxicities. The differences between the specific antibiotics in each class can be subtle, often requiring the expertise of an infectious disease specialist to design the optimal anti-infective regimen. The general internist or physician-in-training should not attempt to memorize all the facts outlined here, but rather should read the pages that follow as an overview of anti-infectives. The chemistry, mechanisms of action, major toxicities, spectrum of activity, treatment indications, pharmacokinetics, dosing regimens, and cost are reviewed.

Antimicrobial therapy: general principles

A wide variety of antimicrobial agents is available to treat established infections caused by bacteria, fungi, viruses, or parasites. This section will cover the general principles of antimicrobial therapy and will also include illustrative clinical problems to emphasize proper decision-making in using antimicrobials.

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Approximately 90-100% of an oral dose of doxycycline hyclate is absorbed from the GI tract in fasting adults. Following oral administration of capsules containing doxycycline hyclate in fasting adults with normal renal function, peak serum concentrations of doxycycline are attained within 1.5-4 hours and average 1.5-2.1 mcg/mL following a single 100-mg dose and 2.6-3 mcg/mL following a single 200-mg dose.

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Doxycycline calcium, doxycycline hyclate, and doxycycline monohydrate are administered orally. When oral therapy is not feasible, doxycycline hyclate may be administered by slow IV infusion; however, oral therapy should replace IV therapy as soon as possible.

Community-Acquired Pneumonia: Current Therapies

Many highly effective agents are available for the treatment of bacterial community-acquired pneumonia (community-acquired pneumonia) and other community-acquire respiratory tract infections (RTIs). Currently marketed antibiotics for community-acquired pneumonia demonstrate similar efficacy rates in clinical trials, and these agents have generally achieved clinical symptom resolution in 85-95% of trial participants.

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The widespread use of tetracyclines has resulted in a steady increase in the prevalence of resistance to these agents. Therefore, empiric use of tetracycline is usually restricted to regions where resistance levels remain low or to cases where other appropriate antibiotics are contraindicated. Although some tetracyclines have very low activity against S. pneumoniae, doxycycline maintains good antipneumococcal activity and is the tetracycline most commonly used for treatment of bacterial community-acquired pneumonia.

Tetracyclines

Tetracyclines are the prototypical broad-spectrum antibiotic and are occasionally used as first-line agents in some markets (e.g., Germany) for the treatment of mild acute exacerbations of chronic bronchitis, particularly when cost, penicillin hypersensitivity, and β-lactam resistance are of concern. The widespread use of tetracyclines has resulted in a steady increase in the prevalence of resistance to these agents. Therefore, empiric use of tetracyclines is usually restricted to regions where resistance levels remain low or when other appropriate antibiotics are contraindicated.

Dosage forms of Doxycycline:
Doxycycline Hyclate 100 mg capsule Doxycycline hyclate 100 mg tablet Doxycycline hyclate 20 mg tablet Doxycycline Monohydrate 50 mg capsule
Vibramycin 100 mg Capsule Doxycycline Monohydrate 100 mg capsule Vibramycin 50 mg capsule Doxycycline hyclate powder
Doxycycline Monohydrate 50 mg tablet Doxycycline mono 50 mg tablet Doxycycline Monohydrate 100 mg tablet Doxycycline mono 75 mg tablet
Periostat 20 mg tablet Doxycycline mono 100 mg tablet Monodox 50 mg capsule Vibramycin 100 mg capsule
Vibra-tabs 100 mg tablet Doryx dr 75 mg tablet Doryx 75 mg Enteric Coated Tabs Doxycycline mono 150 mg tablet
Adoxa 50 mg tablet Doxycycline Monohydrate 150 mg tablet Adoxa pak 1-100 mg tablet Doryx dr 100 mg tablet
Doryx 100 mg Enteric Coated Tabs Monodox 75 mg capsule Avidoxy 100 mg tablet Oracea 40 mg capsule
Oracea 40 mg Delayed Release Capsule Adoxa 75 mg tablet Monodox 100 mg capsule Adoxa 100 mg tablet
Doxycycline hyc 100 mg vial Doryx dr 150 mg tablet Doryx 150 mg Enteric Coated Tabs Adoxa pak 1-150 mg tablet
Vibramycin 25 mg/5ml Suspension 60ml Bottle Apo-Doxy 100 mg Capsule Apo-Doxy 100 mg Tablet Doxycin 100 mg Capsule
Doxycin 100 mg Tablet Novo-Doxylin 100 mg Capsule Novo-Doxylin 100 mg Tablet Nu-Doxycycline 100 mg Capsule
Pms-Doxycycline 100 mg Capsule Pms-Doxycycline 100 mg Tablet Vibramycin 50 mg/5 ml syrup Vibramycin 50 mg/5ml Syrup
Doxycycline Hyclate 50 mg capsule      

Synonyms of Doxycycline:

Doxcycline Anhydrous, Doxycycline Hyclate, Doxycycline Monohydrate, Doxytetracycline

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Therapeutic classes of Doxycycline:

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