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Cefpodoxime is authorised in the world under the following brand names: Banan, Doxef, Vantin.

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Cefpodoxime Proxetil

Cefpodoxime proxetil (Pfizer’s Vantin, Sanofi-Aven-tis’ Orelox, Sankyo’s Banan) is an extended-spectrum, third-generation, oral cephalosporin. Sankyo originally developed cefpodoxime proxetil and first launched the cephalosporin in Japan in 1989. It was marketed in the United States by Upjohn (later Pharmacia) in 1992; Aventis marketed the agent in Europe. A generic version of cefpodoxime developed by Ranbaxy has been approved in the United States. Cefpodoxime is indicated for the treatment of community-acquired pneumonia caused by S. pneumoniae and H. influenzae (including β-lactamase-producing strains).

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Cefpodoxime proxetil is an esterified pro-drug of cefpodoxime created for oral formulation. It is stable in the presence of most β-lactamase enzymes, effectively extending its spectrum of activity against several gram-positive and gram-negative bacteria that are resistant to penicillins and other cephalosporins. However, some extended-spectrum β-lactamase enzymes can inactivate cephalosporins. Clinical studies have shown cefpodoxime to be active against S. pneumoniae, S. aureus, H. influenzae, E. coli, K. pneumoniae, and M. catarrhalis and inactive against enterococci and Pseudomonas species.

In a comparative trial in more than 200 patients with community-acquired pneumonia, 200 mg of cefpodoxime proxetil, administered twice daily for 5 to 10 days, was compared with 500 mg of amoxicillin administered three times daily. The study established that the clinical and bacteriologic efficacy of the two antibiotics were comparable.

In clinical trials of cefpodoxime, 7.0% of treated patients experienced diarrhea, 3.3% reported nausea, 1.0% reported vaginal fungal infections, and 1.2% experienced abdominal pain. The frequency of side effects is similar to frequency associated with other oral cephalosporins.

Cefotaxime

Cefotaxime (Abbott/Sanofi-Aventis’s Claforan, generics) is a third-generation, parenteral cephalosporin available for intravenous (IV) or intramuscular (IM) administration. Cefotaxime was first marketed in 1981 in the United States, where generic versions of the injection are now available. The cephalosporin is also marketed by Roche in Japan.

Cefotaxime

Cefotaxime is stable in the presence of many β-lactamase enzymes, effectively extending its spectrum of activity against a number of gram-positive and gram-negative bacteria resistant to penicillins and other cephalosporins. Clinical and laboratory studies have demonstrated the activity of cefotaxime against S. aureus, S. pneumoniae, and other streptococci. Gram-negative species susceptible to cefotaxime include E. coli, H. influenzae, H. parainfluenzae, K. pneumoniae, and others. It is also active against P. aeruginosa.

Cefotaxime is indicated for treatment of lower respiratory tract infections caused by S. pneumoniae, S. pyogenes, and other streptococci (but not enterococci), S. aureus, E. coli, K. pneumoniae and other Klebsiella species, H. influenzae (including ampicillin-resistant strains), H. parainfluenzae, and Pseudomonas species (including P. aeruginosa). A clinical trial examined the efficacy of cefotaxime in treating patients with severe respiratory infections, including pneumonia. One hundred and ninety patients were treated with 2.25-3.0 g of cefotaxime daily for an average of 9 days and displayed a favorable clinical response in 91% of 184 evaluable cases.

Cefotaxime is generally well tolerated, but some adverse reactions have been documented, including local inflammation at point of IV administration (4.3%) and gastrointestinal disturbances (1.4%). Systemic adverse reactions to cefotaxime have been rare. The frequency of side effects is similar to frequency associated with other parenteral cephalosporins.

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Dosage forms of Cefpodoxime:
Cefpodoxime 100 mg tablet Vantin 100 mg tablet Cefpodoxime 200 mg tablet Cefpodoxime Proxetil 200 mg tablet
Vantin 200 mg tablet Vantin 50 mg/5ml Suspension 50ml Bottle Vantin 50 mg/5ml Suspension 100ml Bottle Vantin 100 mg/5ml Suspension 100ml Bottle
Vantin 20 100 mg tablet Bottle Vantin 20 200 mg tablet Bottle

Synonyms of Cefpodoxime:

Cefpodoxime Proxetil, CPDX-PR, RU 51807

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Therapeutic classes of Cefpodoxime:

Anti-Bacterial Agents, Antibacterial Agents, Cephalosporins

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