Antifungal drugs

Buy Diflucan (Fluconazole) No Prescription 50/100/150/200mg

A white or almost white, hygroscopic, crystalline powder. It exhibits polymorphism. Slightly soluble in water freely soluble in methyl alcohol soluble in acetone.

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Fluconazole is a triazole antifungal used for superficial mucosal (oropharyngeal, oesophageal, or vaginal) candidiasis and for fungal skin infections. It is also given for systemic infections including systemic candidiasis, coccidioidomycosis, and cryptococcosis, and has been tried in blastomycosis, histoplasmosis, and sporotrichosis. The place of fluconazole in the treatment of fungal infections is discussed in the various sections under Choice of Antifungal.

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In general, fewer interactions are considered to occur with fluconazole than with either itraconazole or ketoconazole. Use of rifampicin with fluconazole results in reduced plasma concentrations of fluconazole.

Antifungal Drugs – Targets of Antifungal Activity

Itraconazole is a triazole antifungal drug that is prescribed to patients with fungal infections, blastomycosis, histoplasmosis and onychomycosis. Itraconazole is also prescribed for systemic infections: aspergillosis, candidiasis and cryptococcosis where other antifungal drugs ineffective.

Antifungal Drugs

A number of systemic fungal infections (e.g., histoplasmosis, coccidioidomycosis, and paracoccidioidomycosis) can also afflict otherwise healthy persons. Until recently, only amphotericin B was available to treat systemic fungal infection. However, with the rapid development and clinical assessment of azole compounds, a number of these agents are also considered appropriate for treatment of fungal infections.

Flucytosine (Ancobon 250, 500mg)

While flucytosine may be effective when used alone for the treatment of some fungal infections (e.g., candidal cystitis, chromomycosis), the drug should not be used alone in the treatment of severe, life-threatening infections. In the treatment of serious candidal or cryptococcal infections, flucytosine generally has been used as an adjunct to IV amphotericin B or an azole antifungal agent (e.g., fluconazole, itraconazole). There is some evidence that combined use of flucytosine and amphotericin B may be associated with an increased risk of serious adverse effects, especially in immunocompromised patients including those with human immunodeficiency virus (HIV) infection.

Nystatin – Antifungal Drugs

Nystatin is used orally for the treatment of intestinal candidiasis. In patients with coexisting intestinal candidiasis and vulvovaginal candidiasis, nystatin has been administered orally in conjunction with intravaginal application of an antifungal agent. Nystatin has been administered orally as a suspension in conjunction with local application of the drug for the treatment of candidal diaper dermatitis. The majority of infants with candidal diaper dermatitis harbor C. albicans in their intestines, and infected feces appear to be an important source of the cutaneous infection.

Amphotericin B (Fungilin, Fungizone, Abelcet, Fungisome, Amphocil)

Systematic drug interaction studies have not been performed to date using amphotericin B cholesteryl sulfate complex, amphotericin B lipid complex, or amphotericin B liposomal. The fact that drug interactions reported with conventional IV amphotericin B could also occur with these lipid-based or liposomal formulations of the drug should be considered.

Amphotericin B: Cautions

Acute infusion reactions (e.g., fever, chills, headache, nausea, vomiting) and nephrotoxicity are the most frequent adverse reactions to conventional IV amphotericin B. Although clinical experience with amphotericin B cholesteryl sulfate complex, amphotericin B lipid complex, and amphotericin B liposomal is limited to date, these drugs appear to be better tolerated than conventional IV amphotericin B.

Amphotericin B: Dosage and Administration

Conventional amphotericin B is administered by IV infusion. The drug also has been given intra-articularly, intrapleurally, intrathecally, or by local instillation or irrigation. For information regarding administration of the drug as an oral suspension and administration of the drug topically, subconjunctivally, or by local instillation or irrigation.