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Tetracycline is authorised in the world under the following brand names: Abramycin, Abricycline, Achromycin, Achromycin V, Actisite, Agromicina, Ambramicina, Ambramycin, Amycin, Bio-Tetra, Biocycline, Bristaciclin, Bristaciclina, Bristacycline, Cefracycline, Ciclibion, Copharlan, Criseociclina, Cyclopar, Cytome, Democracin, Deschlorobiomycin, Dumocyclin, Enterocycline, Hostacyclin, Lexacycline, Limecycline, Liquamycin, Medocycline, Mericycline, Micycline, Neocycline, Oletetrin, Omegamycin, Orlycycline, Panmycin, Polycycline, Polyotic, Purocyclina, Resteclin, Retet, Robitet, Roviciclina, SK-Tetracycline, Solvocin, Sumycin, TAC, Tetra-CO, Tetrabon, Tetrachel, Tetracycl, Tetracycline II, Tetracyn, Tetradecin, Tetrafil, Tetramed, Tetraverine, Tetrex, Topicycline, Tsiklomistsin, Tsiklomitsin, Veracin, Vetacyclinum.

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Tetracycline: Drug-Drug Interactions


Co-administration of tetracyclines with antacids or other drugs containing divalent or trivalent cations, such as calcium, magnesium, or iron, is contraindicated. Tetracyclines form complexes with such cations, which are very poorly or not at all absorbed.

To avoid this interaction, delay of 2-3 hours between the ingestion of tetracycline and the cation is recommended. Similarly, reduced systemic availability results from simultaneous intake of abundant quantities of milk or milk products.

Antidiarrheal drugs

Antidiarrheal drugs, such as kaolin-pectin and bismuth products, impair the absorption of tetracyclines by chelation (see the interaction with antacids in this post).

Coumarin anticoagulants

Although antibiotics can inhibit the production of vitamin K in the gut by intestinal bacteria, they do not thereby interfere with the actions of coumarin anticoagulation, since vitamin K that is produced by intestinal bacteria is of less importance than vitamin K that is obtained from dietary sources . Nevertheless, there have been sporadic reports that tetracyclines can enhance the effects of coumarin anticoagulants. The mechanism is not known, but evidence that tetracyclines can reduce the activity of prothrombin suggests an additive pharmacodynamic interaction.


The combination of tetracyclines with diuretics is particularly detrimental to renal function. Tetracyclines accumulate in patients with pre-existing renal insufficiency (for example elderly people, even if the serum creatinine is in the reference range) and can cause nausea and vomiting, which causes dehydration and worsens renal function. This is exacerbated by the effects of diuretics.


See antacids above.


In patients taking oral or parenteral tetracyclines who undergo methoxyflurane anesthesia, renal insufficiency and oxalate crystal formation in renal tissue was attributed to an interaction between these drugs. Tetracyclines are therefore not recommended preoperatively.

Risperidone and/or sertraline

An interaction of tetracycline with risperidone and/or sertraline has been described.

A 15-year-old youth with Asperger's syndrome, Tourette's syndrome, and obsessive-compulsive disorder was stabilized on risperidone 1.5 mg bd and sertraline 100 mg od and had marked improvement in his social skills and tics, until he was given tetracycline 250 mg bd for acne. Within 2 weeks his tics were acutely exacerbated with pronounced neck jerking and guttural sounds. The sertraline was increased to 150 mg/day, but the tics did not resolve. The tetracycline was withdrawn after 1 month, and the tics improved within a few weeks.

The authors reviewed the major metabolic pathways of the three drugs used in this case. Tetracycline may have accelerated the hepatic metabolism of risperidone, but tetracycline has not been shown to induce CYP2D6, the major hepatic enzyme involved in the metabolism of risperidone. The authors claimed that it was more likely that tetracycline binds to risperidone or its active metabolite, making them inactive. They supported this suggestion by citing evidence that clozapine, which has similar pharmacology to risperidone, interacts with tetracycline in vitro.

They also commented on the possibility that the effect could have come from increased concentrations of sertraline, which can increase tics. Tetracycline may inhibit the hepatic enzymes that metabolize sertraline; however, adequate evidence is lacking. Another possibility is a protein binding interaction, because all three drugs are highly protein bound.

However, the observation that the tics were not worsened by an increase in sertraline dosage makes this possibility less likely. The mere fact that the withdrawal of tetracycline resulted in an improvement in the tics supports an interaction between tetracycline and risperidone.

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Dosage forms of Tetracycline:
Tetracycline powder Tetracycline hcl powder Apo-Tetra 250 mg Capsule Tetracycline HCl 250 mg capsule
Tetracycline HCl 500 mg capsule      

Synonyms of Tetracycline:

Anhydrotetracycline, TC, Tetracycline HCl

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Therapeutic classes of Tetracycline:

Anti-Bacterial Agents, Antiprotozoals, Protein Synthesis Inhibitors, Tetracyclines


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