Zyvox (Linezolid)

Zyvox
4.015 ratingsReviews
Generic:
Linezolid
Indications:
infections
Analogs:
Vancomycin Daptomycin Tedizolid Ceftaroline Tigecycline Dalbavancin Oritavancin Clindamycin Linezolid Sivextro Cubicin Teflaro Dalvance Orbactiv Tygacil Bactrim Synercid
Linezolid is an oxazolidinone antibiotic used for certain serious Gram-positive infections (including MRSA and VRE) as prescribed. To get a free extra Zyvox discount coupon, please contact our support team.
In stock: 14 packs
AdultsPregnancyAllergiesDiabetesBreastfeedingChildrenDriving

Dosages

Zyvox 600 mg

Quantity Price per tablet You save Total price
30 $6.08 - $182.50
60 $5.75 $19.90 $345.10

Manufacturers

Accord HealthcareCipla LimitedLaboratorios NormonPfizerPfizer CanadaratiopharmSandoz

Payment & Shipping

Package Example

Your order is carefully packed and ships within 24 hours. Here is what a typical package looks like.

Sized like a regular personal letter (9.4x4.3x0.3 inches), with no indication of what is inside.

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Shipping Times
Shipping MethodEstimated delivery
Express Free for orders over $300.00Estimated delivery to the U.S.: 4-7 days
Standard Free for orders over $200.00Estimated delivery to the U.S.: 14-21 days
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Discount Coupons

  • Independence Day - July 4, 2026 10% JULY410
  • Labor Day - September 7, 2026 7% LABOR07
  • Thanksgiving - November 26, 2026 9% THANKS09

FAQ

A prescription is required to obtain linezolid from local U.S. pharmacies. Our store policy allows customers to order this product without a prescription and have it sent by mail.

Do not save leftover linezolid for a future illness or give it to anyone else. Use a medication take-back program when available, or follow local disposal instructions for unused medicines.

Take the missed dose when you remember unless it is almost time for the next scheduled dose. In that case, skip the missed dose and continue the regular schedule; do not take two doses at once.

Zyvox, the U.S. brand of linezolid 600 mg tablets, is an FDA-approved prescription medicine. The regulatory status of the specific product supplied with an order cannot be confirmed in advance, so it should be verified from the received package label and manufacturer information.

Do not take the tablets if the package strength does not match the ordered 600 mg strength. Keep the medication and all packaging, compare the order details with the package label, and request assistance before using it.

Store the tablets at 77°F; temperature excursions from 59°F to 86°F are permitted. Protect them from light and moisture, and keep the bottle tightly closed.

These tablets are taken by mouth and may be taken with or without food. For many adult indications, the standard regimen is 600 mg every 12 hours, but the course length and exact regimen depend on the infection and the treating clinician's plan.

Linezolid is an oxazolidinone antibiotic used for susceptible Gram-positive bacterial infections, including certain hospital-acquired and community-acquired pneumonias, skin and skin-structure infections, and infections caused by vancomycin-resistant Enterococcus faecium. It does not provide reliable treatment for Gram-negative infections.

Common effects include nausea, diarrhea, headache, vomiting, and changes in taste. Seek prompt medical advice for severe or persistent diarrhea, unusual bruising or bleeding, fever or sore throat, numbness or tingling, or visual changes; blood-count problems and nerve or vision effects are more concerning with longer treatment.

During pregnancy, linezolid should be considered with a clinician because human data are limited and potential benefits must be weighed against possible fetal risk. Linezolid passes into breast milk, so breastfeeding requires caution and an individualized discussion of maternal treatment needs and possible effects on the infant.

Description

Note: Images in the description are provided for informational purposes and may differ from the actual appearance of the product. Please refer to the product name, strength, ingredients, and dosage form.

Zyvox (linezolid) is an oxazolidinone antibiotic used to treat certain serious infections caused by susceptible Gram-positive bacteria.

Drug class

Linezolid belongs to the oxazolidinone class of antibiotics.

How it works

Linezolid inhibits bacterial protein synthesis at an early step by preventing formation of the 70S initiation complex.

What Zyvox tablets treat (and what they do not)

Disease / condition (A-Z) Zyvox tablets
Community-acquired pneumonia (CAP)+
Complicated skin and skin structure infections+
Diabetic foot infection (without concomitant osteomyelitis)+
Gonorrhea
Gram-negative infections (e.g., E. coli, Pseudomonas)
Hospital-acquired / nosocomial pneumonia (HAP)+
Osteomyelitis
Pressure ulcers (decubitus ulcers)
Uncomplicated skin and skin structure infections+
Urinary tract infection (UTI)
VRE (Enterococcus faecium) infection, including cases with concurrent bacteremia+
Viral infections (flu/common cold)
Yeast or other fungal infections

Limitations of use (US): Zyvox is not indicated for the treatment of Gram-negative infections. If a Gram-negative pathogen is suspected or confirmed, appropriate therapy should be started.

Indications (US labeling)

Zyvox tablets are used for certain infections caused by susceptible Gram-positive bacteria, including pneumonia (nosocomial and community-acquired), skin and skin structure infections (complicated and uncomplicated), and vancomycin-resistant Enterococcus faecium (VRE) infections, including cases with concurrent bacteremia.

Tablet strength

  • Tablet: 600 mg (film-coated).

Can you split the tablet?

Zyvox 600 mg tablets are film-coated and are not provided as a scored tablet in US labeling. For this reason, splitting or crushing is generally not recommended unless a clinician specifically instructs it.

Zyvox

Why is Zyvox expensive? Are there alternatives?

Cost can be influenced by brand pricing, manufacturing and supply chain factors, and market conditions. Depending on the infection and culture/susceptibility results, clinicians may choose alternatives. FDA-approved generic linezolid tablets are available in the U.S. and may be lower-cost than the brand in some settings.

What medicines is it used with?

Zyvox may be used alone for confirmed susceptible Gram-positive infections. If an infection is mixed or a Gram-negative pathogen is suspected, clinicians may prescribe Zyvox together with other antibiotics that cover Gram-negative organisms (and, when needed, anaerobes). The exact combination depends on the site of infection, severity, and local resistance patterns.

Drug interactions

Linezolid is a reversible, nonselective MAO inhibitor (MAOI). It can interact with adrenergic drugs (which may raise blood pressure) and serotonergic drugs (which may increase the risk of serotonin syndrome). Tell your clinician about all prescription, over-the-counter, and herbal products you use.

Contraindications

Contraindication What it means
Hypersensitivity to linezolid (or any component of the product) Do not use if you have a known serious allergy to linezolid or product ingredients.
Use with MAO inhibitors (or within 2 weeks of stopping an MAOI) Do not use with MAOIs (e.g., phenelzine, isocarboxazid, selegiline) or within 2 weeks of stopping them due to interaction risk.

Tyramine (food interaction)

Because linezolid has MAOI activity, avoid consuming large amounts of tyramine-rich foods and beverages during treatment. Examples include aged cheeses, cured/aged or improperly stored meats, fermented foods (including some soy/yeast products), and certain alcoholic beverages (such as some beers and red wine). Seek medical help if you develop a severe headache, flushing, or a marked rise in blood pressure.

Side effects and key precautions

Common side effects include diarrhea, nausea/vomiting, and headache.

Important warnings and precautions include myelosuppression (including thrombocytopenia; complete blood counts are commonly monitored weekly), peripheral and optic neuropathy (reported mainly with treatment longer than 28 days), lactic acidosis, seizures, and C. difficile-associated diarrhea. Promptly report unusual bruising/bleeding, severe or persistent diarrhea, or new visual symptoms (blurred vision, changes in visual acuity or color vision).

Storage

  • Store at 77°F (25°C); excursions permitted to 59-86°F (15-30°C).
Medically reviewed by
Donna Brettler
BPharm, MPH - Pharmacologist and medical writer
Updated August 11, 2026

Customer questions

Asked by Margaret M, New York, United States

My linezolid package just arrived. Where should I look for the lot number and expiration date?

Answered by Support team

Check the outer carton and the bottle or blister packaging for the lot number and expiration date. Keep those details with the package, especially if you need to verify the product later.

Asked by Daniel, San Francisco, United States

I take sertraline every day for depression. Can I take this linezolid medicine at the same time?

Answered by Support team
Medical reviewed by Donna Brettler

Linezolid can interact with sertraline because it has reversible MAO-inhibiting activity, increasing the risk of serotonin syndrome. Do not start, stop, or change either medicine on your own; the prescriber needs to determine whether another antibiotic or a supervised treatment plan is appropriate.

Product specifications

Active ingredientLinezolid
Drug classOxazolidinone antibiotic
Dosage formFilm-coated tablet
Available strengths600 mg
RouteOral
StorageStore at 77°F; excursions permitted to 59°F to 86°F. Protect from light and keep bottles tightly closed to protect from moisture.
ATC codeJ01XX08

Regulatory information

Approval StatusLinezolid is approved for human medicinal use in the United States.
Prescription RequirementsA valid doctor's prescription is required to purchase this film-coated tablet.

More information