Bactrim (Sulfamethoxazole and Trimethoprim)

Bactrim
4.76 ratingsReviews
Generic:
Sulfamethoxazole and Trimethoprim
Analogs:
Co Trimoxazole Septra Trimethoprim Nitrofurantoin Fosfomycin Ciprofloxacin Cephalexin Doxycycline Clindamycin Linezolid Atovaquone Dapsone Pentamidine Sulfatrim Levofloxacin
You can buy Bactrim online in the following strengths: 400 mg/80 mg (480 mg total) and Bactrim DS 800 mg/160 mg (960 mg total).
In stock: 14 packs
AdultsPregnancyAllergiesDiabetesBreastfeedingChildrenDriving

Dosages

Bactrim 400mg+80mg

Quantity Price per tablet You save Total price
90 $0.87 - $78.00
120 $0.78 $11.00 $93.00
180 $0.69 $31.00 $125.00
270 $0.67 $53.00 $181.00
360 $0.62 $88.00 $224.00

Bactrim 800mg+160mg

Quantity Price per tablet You save Total price
60 $1.28 - $77.00
90 $1.11 $15.50 $100.00
120 $1.01 $33.00 $121.00
180 $0.92 $66.00 $165.00
270 $0.86 $114.50 $232.00
360 $0.83 $164.00 $298.00

Manufacturers

Alphapharm Pty LtdApotex Inc.Aspen PharmacareAspen Pharmacare AustraliaCipla LimitedNicholas Piramal India Ltd.ratiopharm GmbHRocheRoche S.p.A.Sun Pharmaceutical Industries

Payment & Shipping

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Your order is carefully packed and ships within 24 hours. Here is what a typical package looks like.

Sized like a regular personal letter (9.4x4.3x0.3 inches), with no indication of what is inside.

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Shipping Times
Shipping MethodEstimated delivery
Express Free for orders over $300.00Estimated delivery to the U.S.: 4-7 days
Standard Free for orders over $200.00Estimated delivery to the U.S.: 14-21 days
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Discount Coupons

  • Independence Day - July 4, 2026 10% JULY410
  • Labor Day - September 7, 2026 7% LABOR07
  • Thanksgiving - November 26, 2026 9% THANKS09

FAQ

A prescription is required to obtain sulfamethoxazole and trimethoprim from local US pharmacies. Under our store policy, you may order it without submitting a prescription, and it can be sent by mail.

Take the missed dose when you remember unless it is nearly time for the next dose. If it is nearly time for the next dose, skip the missed dose and resume the regular schedule. Do not take two doses at once.

Not necessarily. Tablet color, shape, size, imprint, packaging, and inactive ingredients can vary between products. The key identifiers are sulfamethoxazole and trimethoprim, the ordered strength of 400 mg/80 mg or 800 mg/160 mg, and the tablet dosage form.

Sulfamethoxazole and trimethoprim is an antibacterial combination used for certain infections caused by susceptible bacteria, including urinary tract infections, some respiratory infections, traveler's diarrhea caused by certain E. coli, and Shigella intestinal infections. It is also used to prevent or treat Pneumocystis jirovecii pneumonia in appropriate patients. It does not treat viral illnesses such as colds or flu.

Description

Note: Images in the description are provided for informational purposes and may differ from the actual appearance of the product. Please refer to the product name, strength, ingredients, and dosage form.

What Is Bactrim?

Bactrim (sulfamethoxazole/trimethoprim) is a combination antibiotic that contains sulfamethoxazole and trimethoprim. It is primarily used to treat various bacterial infections, such as urinary tract infections, ear infections, bronchitis, and pneumonia. The medicine works by inhibiting the production of folic acid in bacteria, which is essential for their growth and survival. This medication is effective against a wide range of bacterial pathogens.

Bactrim (sulfamethoxazole/trimethoprim)

Composition and Active Ingredients

Bactrim is a fixed-dose combination antibiotic that contains two active ingredients:

  • sulfamethoxazole, a sulfonamide antibiotic that inhibits bacterial growth by interfering with the production of folic acid, an essential nutrient for bacteria;
  • trimethoprim, an antifolate antibiotic that works by blocking the enzyme dihydrofolate reductase, which is crucial for synthesizing nucleic acids in bacteria.

Combining these two antibiotics enhances their effectiveness against a broad spectrum of bacterial pathogens. These two active ingredients make Bactrim a versatile treatment option for various infections. The typical ratio in this medicine formulation is one part trimethoprim to five parts sulfamethoxazole, which optimizes their synergistic effects.

Bactrim is rapidly absorbed following oral administration. Both sulfamethoxazole and trimethoprim exist in the blood as unbound, protein-bound, and metabolized forms.

Peak blood levels for the individual components occur 1 to 4 hours after oral administration. The mean serum half-lives of sulfamethoxazole and trimethoprim are 10 and 8 to 10 hours, respectively. However, patients with severely impaired renal function exhibit an increase in the half-lives of both components, requiring dosage regimen adjustment.

The kidneys primarily secrete sulfamethoxazole and trimethoprim through both glomerular filtration and tubular secretion.

Use Cases

Bactrim is indicated for the treatment of numerous bacterial infections, such as:

  • urinary tract infections (UTIs) - effective against common pathogens such as Escherichia coli and Klebsiella;
  • acute otitis media - in pediatric patients, when other treatments may be ineffective;
  • bronchitis - used for acute exacerbations caused by susceptible strains;
  • traveler's diarrhea - effective against enterotoxigenic E. coli;
  • Pneumocystis jirovecii pneumonia (PCP) - used as a preventive measure in immunocompromised individuals, such as those with human immunodeficiency virus (HIV) infection or acquired immunodeficiency syndrome (AIDS).

Additionally, Bactrim can prevent infections like toxoplasmosis and nocardiosis in specific high-risk populations.

Do I Need a Prescription?

Yes, Bactrim is classified as a prescription medication. Contact your healthcare provider. They can evaluate the necessity of the treatment based on the specific infection and patient history. Self-medication with antibiotics can lead to ineffective treatment and contribute to antibiotic resistance.

Sulfamethoxazole/trimethoprim Dosing and Warnings

Bactrim is supplied in various forms, primarily as oral tablets and liquid formulations. The most common tablet strengths include Bactrim 400 mg of sulfamethoxazole combined with 80 mg of trimethoprim. There is also a double strength (DS) version, Bactrim DS, which contains 800 mg of sulfamethoxazole and 160 mg of trimethoprim.

Additionally, Bactrim is available in a liquid form for pediatric use. The dose is adjusted based on the child's weight. These formulations allow for flexibility in dosing depending on the patient's specific needs and the type of infection being treated.

Dosage Form Strength Brand Name Composition/Features
Tablets 400 mg sulfamethoxazole / 80 mg trimethoprim Bactrim Standard formulation
Tablets, DS (Double Strength) 800 mg sulfamethoxazole / 160 mg trimethoprim Bactrim DS Double strength
Oral Suspension 200 mg sulfamethoxazole / 40 mg trimethoprim per 5 mL Bactrim Suspension Sweetened for pediatric use
Intravenous (IV) Solution 80 mg trimethoprim / 400 mg sulfamethoxazole per 5 mL Bactrim IV For hospital use

How and When to Take

To reduce the development of drug-resistant bacteria and maintain the effectiveness of Bactrim (sulfamethoxazole and trimethoprim) tablets and other antibacterial drugs, the medicine should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. Treatment with Bactrim (sulfamethoxazole and trimethoprim) tablets without a proven or strongly suspected bacterial infection or a prophylactic indication is unlikely to benefit the patient. It increases the risk of the development of drug-resistant bacteria.

Bactrim is typically administered twice daily, with or without food. The specific dosage depends on the type of infection being treated:

Condition Patient Group Dosage
Urinary Tract Infections Adults Bactrim DS (800 mg sulfamethoxazole/160 mg trimethoprim) one tablet every 12 hours for 10 to 14 days.
Children (2 months and older) Dosage based on weight: approximately 40 mg/kg sulfamethoxazole and 8 mg/kg trimethoprim daily, divided into two doses.
Acute Otitis Media Children Similar weight-based dosing as for urinary tract infections.
Bronchitis Adults One Bactrim DS tablet every 12 hours for 14 days.

Taking Bactrim at evenly spaced intervals is essential to maintain adequate drug levels in the bloodstream.

If You Forget to Take It

If you miss a dose of Bactrim, take it as soon as you remember. If it's close to the time for your next dose, skip the missed dose-do not double up. Consistency in taking your medication helps maintain its effectiveness.

What to Do in Case of Overdose

In case of an overdose, seek immediate medical attention or contact Poison Control. Symptoms may include nausea, vomiting, dizziness, or confusion. Prompt intervention is essential to manage potential complications from an overdose.

Precautions

Several precautions should be observed when taking Bactrim to ensure safety and effectiveness. As dosage adjustments may be necessary, inform your healthcare provider about any pre-existing medical conditions, particularly kidney or liver issues.

Additionally, Bactrim is not recommended during pregnancy or while breastfeeding due to potential risks to the unborn child or nursing infant. Patients should also be aware of possible allergic reactions. Stop taking it and seek medical attention if severe skin reactions or other serious side effects occur.

Patients should be instructed to maintain adequate fluid intake to prevent crystalluria and stone formation.

When Bactrim (sulfamethoxazole and trimethoprim) tablets are indicated to treat a bacterial infection, patients should be told that although it is expected to feel better early in therapy, the medication should be taken exactly as directed.

Allergy Warnings

Patients with a known allergy to sulfonamide antibiotics should avoid taking Bactrim due to the risk of severe allergic reactions, including Stevens-Johnson syndrome, anaphylaxis, toxic epidermal necrolysis, allergic myocarditis, exfoliative dermatitis, erythema multiforme, angioedema, drug fever, Henoch-Schönlein purpura, chills, serum sickness-like syndrome, generalized skin eruptions, generalized allergic reactions, photosensitivity, conjunctival and scleral injection, pruritus, urticaria, and rash. Periarteritis nodosa and systemic lupus erythematosus have also been reported. It is crucial to inform healthcare providers about any previous allergic reactions before treatment.

Health Conditions Warnings

Individuals with certain health conditions should use Bactrim cautiously:

  • patients with impaired renal function may require dosage adjustments due to reduced clearance of the drug;
  • caution is advised for patients with liver impairment, as this can affect drug metabolism;
  • patients with conditions such as porphyria or megaloblastic anemia should avoid this medication unless specifically directed by their physician.

This medication is contraindicated in pediatric patients younger than 2 months of age.

Fatalities associated with the administration of sulfonamides, although rare, have occurred due to severe reactions, including Stevens-Johnson syndrome, fulminant hepatic necrosis, aplastic anemia, toxic epidermal necrolysis, agranulocytosis, and other blood dyscrasias.

AIDS patients may not tolerate or respond to Bactrim in the same manner as non-AIDS patients.

Regular monitoring may be necessary during treatment for those with pre-existing conditions.

Sulfamethoxazole/trimethoprim Side Effects

Common side effects associated with Bactrim include:

  • nausea and vomiting;
  • rash or itching;
  • diarrhea.

Serious side effects can occur but are rare; these include:

  • severe allergic reactions (e.g., Stevens-Johnson syndrome, anaphylaxis, toxic epidermal necrolysis, allergic myocarditis, exfoliative dermatitis, erythema multiforme, angioedema, drug fever, Henoch-Schönlein purpura, chills, serum sickness-like syndrome, generalized skin eruptions, generalized allergic reactions, photosensitivity, conjunctival and scleral injection, pruritus, urticaria, and rash; periarteritis nodosa and systemic lupus erythematosus have been reported);
  • blood disorders such as thrombocytopenia or leukopenia;
  • gastrointestinal: hepatitis (including cholestatic jaundice and hepatic necrosis), elevation of serum transaminase and bilirubin, pseudomembranous enterocolitis, stomatitis, pancreatitis, glossitis, nausea, abdominal pain, emesis, diarrhea, anorexia;
  • neurologic: convulsions, aseptic meningitis, peripheral neuritis, vertigo, ataxia, tinnitus, headache;
  • psychiatric: depression, nervousness, hallucinations, apathy;
  • endocrine: the sulfonamides bear certain chemical similarities to some goitrogens, diuretics (acetazolamide and the thiazides), and oral hypoglycemic agents; cross-sensitivity may exist with these agents. Diuresis and hypoglycemia have occurred rarely in patients receiving sulfonamides;
  • musculoskeletal: arthralgia and myalgia; isolated cases of rhabdomyolysis have been reported with Bactrim, mainly in AIDS patients;
  • respiratory: cough, shortness of breath, and pulmonary infiltrates;
  • miscellaneous: fatigue, weakness, insomnia.

Clinical signs, such as rash, sore throat, fever, arthralgia, pallor, purpura, or jaundice, may indicate severe reactions.

Patients should promptly report any unusual symptoms or side effects to their healthcare provider.

Interactions with Other Medicines

Bactrim can interact with several medications, which may increase the risk of adverse effects or reduce therapeutic effectiveness. The interactions include:

  • warfarin (increased risk of bleeding due to enhanced anticoagulant effect);
  • methotrexate (potentially increased toxicity due to similar mechanisms affecting folate metabolism);
  • diuretics (certain diuretics may increase potassium levels when taken with Bactrim).

Always inform your healthcare provider about all medications you are currently taking, including over-the-counter drugs and supplements, to avoid potential interactions.

After Using Bactrim Medication

After using Bactrim medication, it is essential to store it properly. Unused or expired pills should also be disposed of properly.

Storage

Bactrim should be stored at room temperature, away from moisture and heat sources. Keep it out of reach of children and pets. Proper storage helps maintain the medication's effectiveness throughout its shelf life.

Disposal

Do not flush unused or expired pills down the toilet unless instructed. Consult your pharmacist for safe disposal methods or local guidelines on medication disposal.

Bactrim (sulfamethoxazole/trimethoprim) is a powerful combination antibiotic that effectively treats many bacterial infections. Understanding its composition, uses, precautions, dosing guidelines, potential side effects, and interactions with other medications is crucial for safe and effective use. Always follow your healthcare provider's instructions regarding its use and report any adverse effects or concerns during treatment.

Medically reviewed by
Brian Holtry
MD, infectious diseases specialist and medical writer
Updated August 11, 2026

Customer questions

Asked by Maria, San Jose, United States

My Bactrim package arrived with a torn seal. Can I still use the tablets if they look normal?

Answered by Support team

Do not use tablets from a package whose seal or physical condition appears compromised until the discrepancy has been checked. Keep the package, including its label and lot information, available for verification.

Asked by Derek, Dallas, United States

I used a liquid version of this medicine before. What form do you sell?

Answered by Support team

This product is supplied as oral tablets only. The listed tablet strengths are 400 mg/80 mg and 800 mg/160 mg of sulfamethoxazole and trimethoprim.

Asked by Anthony, El Paso, United States

Will the package I receive say Bactrim, or could it have a different name on it?

Answered by Support team

The exact trade name on the package is not guaranteed and may be a generic or manufacturer name. Verify the package states sulfamethoxazole and trimethoprim, matches your ordered strength, and identifies the product as tablets.

Asked by Danielle, Washington, D.C., United States

When my order arrives, where should I look for the lot number and expiration date?

Answered by Support team

Check the outer carton, blister pack, bottle, or package label for the lot number and expiration date. The exact placement varies by manufacturer, so use the information printed on the medicine package you receive.

Asked by Kevin, San Diego, United States

I take losartan for blood pressure. Is there anything important to know before I start these tablets?

Answered by Support team
Medical reviewed by Donna Brettler

Trimethoprim can raise potassium levels, and the risk is higher when it is combined with losartan or other ARB blood-pressure medicines. A clinician or pharmacist should review the combination before treatment, especially if you have kidney problems or use potassium supplements.

Product specifications

Active ingredientSulfamethoxazole and trimethoprim
Drug classSulfonamide antibiotic combination
Dosage formTablets
Available strengths400 mg/80 mg; 800 mg/160 mg
RouteOral
StorageStore at 68°F to 77°F, and protect from light.
ATC codeJ01EE01

Regulatory information

Approval StatusThis active ingredient combination is approved by the FDA for human medicinal use in the United States.
Prescription RequirementSulfamethoxazole and trimethoprim tablets are classified as prescription-only medication and require a valid prescription from a licensed healthcare provider.

More information