
Bifonazole is an imidazole antifungal with a broad spectrum of activity sensitive fungi include dermatophytes, Malassezia furfur, and Candida spp. It also has some antibacterial activity.
Amorolfine is a morpholine derivative with antifungal activity. It appears to act by interfering with the synthesis of sterols essential for the functioning of fungal cell membranes. Amorolfine is active in vitro against a wide variety of pathogenic and opportunistic fungi including dermato-phytes, Blastomyces ckrmatitidis, Candida spp., Histoplasma capsulatum, and Sporothrix schenckii. It also has variable activity against Aspergillus spp.
Amphotericin B is active against Absidia spp., Aspergillus spp., Basidiobolus spp., Blastomyces dermatitidis, Candida spp., Coccidioides immitis, Conidiobolus spp., Cryptococcus neoformans, Histoplasma capsulatum, Mucor spp., Paracoccidioides brasiliensis, Rhizopus spp., Rhodotorula spp., and Sporothrix schenckii.
According to the American Lung Association, chronic bronchitis affects approximately 5.4 percent of the population, or 14.2 million people, in the United States. The condition has been slightly more prevalent in men than in women, but chronic bronchitis affects people of all ages. The highest incidence rate has been found in people over 50 years old.