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Amorolfine

Amorolfine

Drug Nomenclature

Synonyms: Amorolfiini; Amorolfin; Amorolfina; Amorolfinum; Ro-14-4767/000

BAN: Amorolfine
USAN: Amorolfine
INN: Amorolfine [rINN (en)]
INN: Amorolfina [rINN (es)]
INN: Amorolfine [rINN (fr)]
INN: Amorolfinum [rINN (la)]
INN: Аморольфин [rINN (ru)]
Chemical name: (±)-cis-2,6-Dimethyl-4-[2-methyl-3-(ptert-pentylphenyl)propyl]morpholine
Molecular formula: C21H35NO =317.5
CAS: 78613-35-1
ATC code: D01AE16

Amorolfine

Amorolfine Hydrochloride

Drug Nomenclature

Synonyms: Amorolfina, hidrocloruro de; Ro-14-4767/002
BAN: Amorolfine Hydrochloride [BANM]
INN: Amorolfine Hydrochloride [rINNM (en)]
INN: Hidrocloruro de amorolfina [rINNM (es)]
INN: Amorolfine, Chlorhydrate d’ [rINNM (fr)]
INN: Amorolfini Hydrochloridum [rINNM (la)]
INN: Аморольфина Гидрохлорид [rINNM (ru)]
Molecular formula: C21H35NO,HCl =354.0
CAS: 78613-38-4
ATC code: D01AE16

Amorolfine Hydrochloride

Adverse Effects

Skin irritation, presenting as erythema, pruritus, or a burning sensation, and, rarely, more severe skin reactions have been reported after topical application of amorolfine.

Antimicrobial Action

Amorolfine is a morpholine derivative with antifungal activity. It appears to act by interfering with the synthesis of sterols essential for the functioning of fungal cell membranes. Amorolfine is active in vitro against a wide variety of pathogenic and opportunistic fungi including dermato-phytes, Blastomyces ckrmatitidis, Candida spp., Histoplasma capsulatum, and Sporothrix schenckii. It also has variable activity against Aspergillus spp. However, despite its in vitro activity, amorolfine is inactive when given systemically and this limits its use to topical application for superficial infections.

Uses and Administration

Amorolfine is a morpholine derivative applied topically as the hydrochloride in the treatment of fungal nail and skin infections. After topical application, systemic absorption of amorolfine is negligible. For the treatment of nail infections caused by dermato-phytes, yeasts, and moulds a lacquer containing the equivalent of 5% amorolfine is painted onto the affected nail once or sometimes twice weekly until the nail has regenerated. Treatment generally needs to be continued for 6 to 12 months. For skin infections, including dermatophyte infections, a cream containing the equivalent of 0.25% amorolfine is applied once daily for at least 2 to 3 weeks (up to 6 weeks for foot infections) and continued for 3 to 5 days after clinical cure is achieved.

Preparations

Proprietary Preparations

Argentina: Loceryl Locetar  Micocide A Australia: Loceryl Austria: Loceryl Belgium: Loceryl Brazil: Loceryl Chile: Loceryl Czech Republic: Loceryl Denmark: Loceryl Finland: Loceryl France: Loceryl Germany: Loceryl Greece: Loceryl Hong Kong: Loceryl Hungary: Loceryl Ireland: Loceryl Italy: Locetar Japan: Pekiron Malaysia: Loceryl Mexico: Loceryl Norway: Loceryl New Zealand: Loceryl Philippines: Locetar Poland: Loceryl Portugal: Locetar Russia: Loceryl Singapore: Loceryl Spain: Locetar Odenil Sweden: Loceryl Switzerland: Loceryl UK: Curanail Loceryl Venezuela: Loceryl

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