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Tretinoin Cream

What Is Tretinoin Cream?

The benefits of Tretinoin cream go beyond clearing the skin of acne. For example, people who have post-inflammatory hyperpigmentation may find that Tretinoin cream reduces the appearance of dark spots and discolors remaining blackheads.

Tretinoin cream 0.05

What is tretinoin cream used for: Tretinoin cream is successful in fighting wrinkles and is often used in cosmetics as an agent in fighting signs of skin withering and aging. All tretinoin products work by accelerating cell renewal. There is a rapid exfoliation of the skin and a reduction in the accumulation of dead cells inside the follicle. This in turn reduces the formation of comedones.


Tretinoin (Retinoic Acid) and other retinoids are effective in treating acne mainly by normalizing sebum levels, anti-inflammatory effects, and thinning of the stratum corneum. Сream tretinoin has been approved by the FDA as a treatment for wrinkles. No retinoid has been subjected to as much research on wrinkles as tretinoin.

Tretinoin Groups

In 1988, retinyl palmitate was shown to not only increase epidermal thickness but also increase collagen content in the dermal layer. The biologically active form of vitamin A, known clinically as tretinoin, starts working much faster than retinol but has a high irritant potential.

Less irritating (compared to tretinoin) retinol derivatives are retinyl palmitate (A palmitate) or retinyl acetate (A acetate) esters, they are more stable, have low irritation potential, and are not toxic. Compared to tretinoin, esters have lower permeability through the stratum corneum. However, with proper selection of the concentration and composition of the other components, retinoic acid esters not only penetrate the skin but also have a physiological effect.

What’s The Difference Between Tretinoin And Retinol

Many people often confuse retinol with tretinoin. Retinol and retinoic acid are related but distinctly different. Retinols must first be converted by special enzymes into the active metabolite, retinoic acid. Only retinoic acid directly affects skin cells and helps reduce the signs of aging. Tretinoin, on the other hand, is already retinoic acid and does not need this conversion.

In theory, you should be able to apply retinol to your skin, wait for it to convert to retinoic acid, and then eventually get the benefit of the acid. In reality, the conversion rate is low and varies greatly among people.

In addition, in contact with air during storage or use, large amounts of retinol can oxidize or degrade even before it is available to convert to retinoic acid in the skin. As a result, most retin-a tretinoin creams show better results in a small number of people than creams containing retinoic acid (Retin-A tretinoin). The degree of irritation and other reactions tends to be less as well.

Also, your retinol should be packaged hermetically to ensure maximum retinol effectiveness. However, when trying to get a quick effect and more significant skin change, the patient should look into. It is tretinoin that is the form of retinoic acid that will provide more significant changes. However, in many countries, Tretinoin is only available by prescription, as opposed to more affordable and readily available retinol preparations.

Tretinoin Cream Uses

Recommendations Tretinoin cream uses:

  • Clean the skin of the area to be treated before application. Wait 20 minutes after washing.
  • With a light touch evenly apply the cream on the affected surface (usually applied once a day in the evening). Later it is possible to apply 1-2 times a day for 1-6 hours, then rinse with water.
  • Period of application: 4-6 weeks (up to 14 weeks). For preventive purposes – 1-3 times a week for a long time (after treatment with warm water). For people with light and dry skin, the time of exposure in the beginning of application is 30 minutes, then the duration of exposure is gradually increased.
  • Wash your hands after its application. Also, avoid using other products on the treated areas for at least 1 hour after application.
  • After applying the cream, you may feel the warmth and a slight burning sensation.
  • The amount for one application is about the size of a pea. Too much product is not good for you.
  • Do not use the cream on the skin under the eyes or very close to that area. The areas around the mouth and the nasolabial folds should also be avoided (the skin there is comparatively thin, and you do not want to encourage flaking).

Use a moisturizer daily. Be careful in your choice of skincare products. Abrasive scrubs, astringents, aftershave lotions, and exfoliating products can cause burning and discomfort. You should protect treated areas of your skin from sunlight – use sunscreen.

Treating The Acne

Pimples occur suddenly and can easily ruin not only your appearance but also your mood. On the query “treatment of acne” on Google you will find many recipes for home masks, but they give only cosmetic results and are often not effective at all. All because acne or acne, as they call it in medical circles, is not a cosmetic defect, but a marker that indicates a malfunction in the body. Today we will learn what acne is and how it appears, how to treat acne and avoid complications.

The treatment of acne must be approached systematically. Masking the rashes is not only ineffective but also harmful: in this way you can aggravate the condition of your skin. No matter how convincing the advertising is, there is no single magic cure for acne that is suitable for everyone and helps to cope with the disease once and for all. Only a doctor can determine the cause for which you have acne and prescribe a competent treatment regimen.

Tretinoin is one of the structural analogs of vitamin A, also known as trans-retinoic acid. The latter belongs to the 1st generation of retinoids, and its formula was developed specifically for the treatment of acne (acne and pimples). Numerous studies have shown that it is trans-retinoic acid that is the strongest and most effective form of vitamin A. It has also been observed in studies that tretinoin also helps to reduce the depth of wrinkles.

Sun-damaged Skin

Besides, it is very important to use sunscreens with SPF 50 (in spring and summer) together with Tretinoin cream, as well as moisturizers to prevent skin dryness and irritation. All products must be non-comedogenic! On the contrary, using oily products that clog pores will only make your acne and pimples worse.

Fine Wrinkles

Retinoids other than retinoin are used nowadays for the correction of wrinkles – first of all, they are products with pure retinol (you shouldn’t mix it up with retinol acetate or palmitate) and also retinaldehyde or isotretinoin. However, to date, of all retinoids it is tretinoin that is the most studied drug. We will show you reviews for Tretinoin anti-wrinkle cream from clinical studies and before-and-after photos of patients.

How To Apply Tretinoin Retin A On Your Skin

A cream drops the size of a pea is usually enough for 1 application. The first visible result will not be visible before 4 weeks from the start of therapy. Satisfactory results will not appear before 8-12 weeks. A full course tretinoin Retin a cream of treatment is not less than 3 months. It is worth bearing in mind that if tretinoin is used in papulopustular acne (pimples), it is normal that in the first 2 weeks you will first notice a deterioration in the condition of the skin of the face. There is no need to stop the drug in this case.

Dosage And Administration

How to use tretinoin cream: Using products with a concentration of tretinoin of 0.01% or lower has proven futile since studies have shown no difference in the skin before and after using such a concentration. Only after several months of using tretinoin cream 0.025% tretinoin and getting the skin used to it could one switch to a higher concentration of 0.05 tretinoin cream.

What Are Tretinoin Side Effects

There are several common Tretinoin side effects, which may include increased sensitivity to sunlight, dry skin, nausea, persistent or worsening irritation, blistering, crusting, swelling, excessive redness, temporary change in skin pigmentation, and headaches. This medication can potentially cause more serious side effects, including a condition known as retinoic acid-APL syndrome. Patients taking this medication should monitor side effects and any changes in their condition so they can report problems to their doctor.

Retinoic Acid & Derivatives

Overdosage & Contraindications

  • Do not exceed the recommended dose. Excessive use of the drug will not relieve your condition and may cause poisoning and serious side effects. If you know of a Tretinoin Cream / Tretinoin Cream overdose, contact the emergency services, the nearest hospital or hospital. Be sure to take the package, container or name of the drug with you to facilitate diagnosis.
  • Do not give your medication to others, even if they are in the same condition as you, or you think your conditions have a number of similar signs, as this can lead to an overdose.
  • Please consult your doctor or pharmacist and read the information on the product package.

What Should You Tell Your Doctor Before Using Tretinoin

Before you start taking this medicine, tell your doctor about any medications, supplements (e.g., vitamins, natural supplements, etc.), allergies, existing illnesses, and current health conditions (e.g., pregnancy, upcoming surgery, etc.) you are already taking. The side effects of the drug may be more pronounced if you have a certain condition of your body. Take the medicine as directed by your doctor or follow the instructions for use that come with the medicine.


Pregnant and nursing women should always consult their doctor before using products containing Tretinoin, as dermatologist reviews repeatedly state. Since these products are absorbed through the skin and can potentially cause harm. But it is best to avoid using this group of products altogether during pregnancy and lactation.


Pain during injections may cause uterine tone and, in breastfeeding mothers, cessation of lactation. Some drugs are absorbed into the blood and, once in the milk, are passed on to the baby, or are passed through the placenta into the fetal bloodstream. Tell your doctor about all the medicines, vitamins, and supplements you use. Your doctor will be able to make a proper medication plan to avoid negative interactions.

Sun Exposure

Take care of your skin from the sun and use sunscreen.  Tretinoin makes your skin more sensitive, including to the sun. Unprotected sun exposure can cause burns and age spots. And according to cosmetologists, removing pigmentation is one of the hardest things to do. Use broad-spectrum products that protect against both types of sunlight. Usually, they have broad-spectrum, UVA/UVB protection, and Japanese products have PA+++ as well. Wear sunscreen even if you’re not out for a walk, but sit/work at home by an open window.


Tretinoin tends to interact poorly with other medications known to have the effect of drying or thinning the skin, especially medications with sulfur or salicylic acid.

Drugs Or Supplements Interactions

For example, there are combination products where the topical retinoid adapalene 0.1% is combined – either with the antibiotic clindamycin or peroxide. In addition, monotherapies with 0.1% adapalene (Klenzit, Differin) can easily be combined with monotherapies based on benzoyl peroxide, dividing their use into morning/evening sessions. But products with tretinoin cannot be combined with anything other than antibiotics. The fact is that benzoyl peroxide has a pronounced irritant effect on the skin, and it cannot be used together with tretinoin.

How The Medication Is Supplied


RETIN-A Strength/ Form


RETIN-A Liquid

NDC Code


NDC Code

RETIN-A Strength/ Form


NDC Code

RETIN-A Strength/ Form



0.025% Cream



0.01% Gel



0.05% Liquid




0.025% Cream



0.01% Gel









0.025% Gel






0.05% Cream



0.025% Gel






0.1% Cream









0.1% Cream








Storage And Disposal Of This Medication

Store preparations at room temperature, in a cool place and away from direct sunlight. Do not freeze medications unless specifically asked for in the instructions. Keep medicines away from animals and children.

Do not flush medications down toilets or drains unless explicitly stated. Medicines disposed of in this way can be very harmful to the environment. Contact your doctor for more information on the disposal of Tretinoin Cream.

Alternatives To Tretinoin Cream

One alternative is to use isotretinoin topical products, which also belong to the retinoid group (structural analogs of vitamin A).

Tips for Treating Dry Skin from Retin-A

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