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Hexigel (Chlorhexidine topical 1%) – Oral Antiseptic Gel

Hexigel (Chlorhexidine 1%) is a topical oral gel commonly used to treat various oral conditions. It contains the active ingredient chlorhexidine gluconate 1%, which is an antiseptic and disinfectant agent. Chlorhexidine gluconate has broad-spectrum antimicrobial properties, which can effectively kill or inhibit the growth of a wide range of microorganisms, including bacteria, viruses, and fungi.


What is Chlorhexidine Topical 1%?

Hexigel is primarily used for the management of gum infections and oral ulcers. Dentists often prescribe it to help control and prevent oral infections, particularly in gingivitis (gum inflammation) or periodontitis (gum disease). The gel is applied topically to the affected areas inside the mouth, where it helps reduce inflammation and control the growth of bacteria, promoting healing.

In addition to its use for gum infections, Hexigel can also be beneficial in treating oral ulcers, including canker sores. It helps to alleviate pain, reduce inflammation, and prevent secondary infections in these conditions.

Hexigel may be recommended after specific dental procedures, such as tooth extraction or oral surgery, to help prevent infection and promote healing.

Some individuals with a higher risk of oral infections, such as those with compromised immune systems or certain medical conditions, may use Hexigel as part of their regular oral hygiene routine to maintain oral health and prevent infections.

As with any medication, it is advisable to consult a healthcare professional, such as a dentist or doctor, before using Hexigel to ensure its suitability for your specific condition and to receive appropriate dosage instructions.

NDC codes is 0121-0893-16, 68599-5400-1, 68599-5400-2, 68599-5400-3

Clinical Pharmacology

Chlorhexidine exhibits its antimicrobial effects through several mechanisms of action. Here is an overview of the mechanism of action of chlorhexidine topical 1%.

Chlorhexidine can disrupt the integrity of microbial cell membranes. It binds to the microbial cell wall’s negatively charged components, causing cellular contents’ leakage and ultimately leading to cell death.

Chlorhexidine has a broad spectrum of antimicrobial activity, which means it is effective against a wide range of microorganisms, including bacteria, viruses, and fungi. It targets both Gram-positive and Gram-negative bacteria, as well as certain yeasts and enveloped viruses.

Chlorhexidine has the property of substantivity, which means it has a prolonged and persistent antimicrobial effect even after its initial application. It binds to oral surfaces and slowly releases over time, providing sustained antimicrobial action.

Chlorhexidine can inhibit microorganisms’ initial attachment and colonization on surfaces such as teeth and oral tissues. Reducing the adherence of bacteria and other microbes, it helps prevent the formation of dental plaque and biofilms, which are key contributors to oral infections.

This active ingredient possesses anti-inflammatory properties, which can help reduce inflammation associated with oral infections and promote healing.


Hexigel’s active ingredient is chlorhexidine gluconate, which is present in a concentration of 1.0% w/w in the gel. It is formulated in a pleasantly flavored base, making it more enjoyable to use. Hexigel is available in a presentation of a 15g (0.52 oz) tube.


What Are the Dosages of Chlorhexidine topical 1%?

It is important to note that Hexigel is a topical treatment and should not be swallowed. It is typically applied to the affected area using a clean finger or a cotton swab, following the instructions provided by a healthcare professional or as indicated on the product packaging. After application, avoid eating or drinking for at least 30 minutes to allow the gel to exert its effect.

The specific instructions for using Hexigel may vary based on your condition and the recommendations provided by your healthcare professional. 

The recommended dosage of Hexigel is typically a pea-sized amount or as directed by your healthcare professional. Avoid excessive use of the gel.

The frequency of Chlorhexidine topical 1% application may vary, but it is generally used 2 to 3 times a day or as directed by your healthcare professional. It’s essential to maintain regular use as advised for the prescribed duration. The duration of gel usage will depend on the specific condition being treated. 

Hexigel is often used as part of an overall oral hygiene routine. It should not replace regular brushing, flossing, or other oral care practices recommended by your dentist.

Important Safety Information

While Hexigel is generally safe for topical use, it is crucial to be aware of certain safety information and precautions. Here are some important points to consider:

  • Hexigel is intended for topical use inside the mouth and should not be swallowed. Use the gel as directed and avoid ingestion.
  • Some individuals may be allergic to chlorhexidine or other ingredients in Hexigel. If you experience signs of an allergic reaction such as itching, rash, swelling, or difficulty breathing, discontinue use and seek immediate medical attention. Some people may experience side effects. Contact your doctor if they persist or worsen.
  • Hexigel should not come into contact with the eyes. In case of accidental contact, rinse thoroughly with water and seek medical assistance if irritation persists.
  • Before using Hexigel, it is advisable to consult your healthcare professionals, such as a dentist or doctor, especially if you have any pre-existing medical conditions or allergies or are taking other medications.
  • If you are pregnant, planning to become pregnant, or breastfeeding, it is essential to inform your healthcare professional before using Hexigel to ensure its safety in these situations.
  • Hexigel is generally safe for use in children. Still, it is essential to follow the guidance of a healthcare professional regarding dosage and frequency of use for children.
  • Hexigel may interact with other oral care products or medications. It is recommended to consult your healthcare professional or dentist regarding any potential interactions before using Hexigel alongside other products.
  • Follow the instructions provided by your healthcare professional or as indicated on the product packaging for proper dosage, frequency, and duration of use.


In many countries, Hexigel is available over the counter, which means you can purchase it without a prescription. However, regulations regarding the sale and availability of Hexigel can vary depending on the country or region. Some countries may classify it as a non-prescription medication, while in others, it may require a prescription from a healthcare professional.

Contraindications to Hexigel

There are a few contraindications to consider before using Hexigel. It is important to note that these contraindications may vary.

Individuals with known hypersensitivity or allergy to chlorhexidine or any other ingredient in Hexigel should avoid using it. Allergic reactions can range from mild skin irritation to severe reactions, including anaphylaxis.

Chlorhexidine 1% should not be applied to open wounds, cuts, or areas of significant oral trauma. It is intended for topical use on intact oral tissues.

The gel should not come into contact with the eyes or be introduced into the ear canal. It is formulated for use inside the mouth only.

In cases of deep oral or periapical infections, Hexigel may not be sufficient for effective treatment. These conditions often require more comprehensive dental or medical interventions.

If you have pre-existing oral mucosal lesions, such as erosions, severe ulcerations, or traumatic lesions, it is advisable to consult a healthcare professional before using Chlorhexidine 1% to ensure its suitability and appropriate management of your condition.

Side Effects

While Hexigel is generally considered safe for topical use, some individuals may experience certain side effects. The most common side effects of Hexigel include:

  1. Temporary Oral Discoloration: Hexigel may cause temporary teeth, tongue, or oral tissue discoloration. This usually subsides after discontinuing the use of the gel and proper oral hygiene practices.
  2. Taste Alteration: Some individuals may experience a temporary alteration in taste perception while using Chlorhexidine 1%l. This can cause a bitter or metallic taste in the mouth.
  3. Oral Irritation or Burning Sensation: In some cases, the gel may cause mild irritation or a burning sensation in the oral cavity. This is usually temporary and resolves on its own.
  4. Dry Mouth: Hexigel may contribute to a temporary sensation of dryness in the mouth. Maintaining proper hydration and regular oral care can help alleviate this symptom.
  5. Allergic Reactions: Although rare, some individuals may experience allergic reactions to Chlorhexidine 1%. Signs of an allergic reaction may include itching, rash, swelling, or difficulty breathing. If you experience these symptoms, discontinue use and seek immediate medical attention.

It is important to note that these side effects are generally mild and temporary. If you experience persistent or severe side effects, it is recommended to consult your healthcare professional or dentist for further evaluation and guidance.

Additionally, inform your healthcare professional about any pre-existing medical conditions or allergies you may have before using Hexigel to ensure its suitability and safety for you.

Interactions of Hexigel With Other Medicines

When using Hexigel, there are generally no significant known interactions with other medications. Since Hexigel is used topically inside the mouth, its systemic absorption is minimal, which reduces the likelihood of interactions with other medications. However, it is still advisable to inform your healthcare professional or dentist about any medications you are taking to ensure no potential interactions or contraindications specific to your situation.

Here are a few points to consider regarding the potential interactions of Hexigel with other medicines:

  1. Mouthwash or Oral Care Products: Hexigel is often used as part of an oral hygiene routine. It is generally safe to use alongside other mouthwash or oral care products. However, it is recommended to space out different oral care products to allow sufficient time for each product to take effect.
  2. Medications Containing Anionic Agents: Hexigel may be less effective when used simultaneously with certain anionic agents, such as sodium lauryl sulfate, commonly found in some toothpaste formulations. These agents can reduce the antimicrobial activity of chlorhexidine. Suppose you are using a toothpaste containing sodium lauryl sulfate. In that case, it is advisable to rinse your mouth thoroughly and wait for some time before applying Hexigel to optimize its effectiveness.
  3. Medications that Alter Oral pH: Some medications, such as certain antacids or medications used for gastric reflux, can alter the pH balance in the mouth. Significant changes in oral pH may affect the efficacy of chlorhexidine. If you are taking such medications, it is best to consult your healthcare professional or dentist for guidance on using Hexigel appropriately.

It is important to note that the above information provides general guidance, and specific interactions can vary depending on the medications involved and individual circumstances. 


Overdose of Hexigel

Avoid excessive use or accidental ingestion, which can lead to potential complications. If you suspect an overdose or have concerns about using gel, it is recommended to seek medical attention or contact a poison control center immediately. 

In case of accidental ingestion, seek medical attention immediately, even if there are no immediate symptoms. The healthcare professional can assess the situation and provide appropriate guidance.

Using more gel than the recommended dosage or applying it more frequently than advised may increase the risk of side effects. Strictly adhere to the recommended dosage and frequency your healthcare professional provides or as indicated on the product packaging.

Overdosing on Hexigel can increase the likelihood and severity of side effects such as oral discoloration, taste alteration, oral irritation, or dry mouth. If you experience severe or persistent side effects, seek medical attention.

In case of an overdose or accidental ingestion, seeking immediate medical assistance or contacting a poison control center is crucial. They can provide specific advice based on your situation and offer appropriate guidance to manage the situation effectively.


Store Hexigel in a cool, dry place away from direct sunlight, heat sources, and excessive moisture. Exposure to extreme temperatures or humidity can affect the stability and efficacy of the product.

The gel should be stored at room temperature, typically between 20°C and 25°C (68°F and 77°F). Ensure that the cap or lid of the container is tightly closed after each use to prevent contamination and maintain the integrity of the gel. Store the product in a secure location that is out of reach of children and pets to prevent accidental ingestion. Before using Hexigel, always check the expiry date on the packaging. Do not use the product if it has expired.

Benefits of Using Hexigel

Antimicrobial Action
  • effective against bacteria, viruses, and fungi;
  • helps prevent and reduce oral infections.
Reduction of Plaque and Biofilm Formation
  • inhibits plaque accumulation and biofilm formation;
  • supports good oral hygiene and prevents dental issues.
Gum Health Promotion
  • reduces inflammation and bacterial load in the gums;
  • beneficial for gum diseases like gingivitis.
Post-Dental Procedure Care
  • prevents infection and supports healing after procedures;
  • promotes a healthy oral environment.

Convenience and Ease of Use

  • user-friendly gel form for easy application;
  • can be incorporated into an oral hygiene routine.

Localized Treatment

  • targets affected areas within the oral cavity;
  • acts directly on gums, teeth, and oral tissues.

Generic and Brand Names of Hexigel

In addition to the brand name “Hexigel,” chlorhexidine gluconate 1% can be found under various other names. Here are some examples:

  • Chlorhexidine Gluconate Gel 1%
  • Peridex
  • Periogard
  • Hibiclens
  • Corsodyl Gel
  • Savacol Gel
  • Chlorhex
  • Chlorhexidine Oral Rinse
  • Chlorohex
  • Chlorostat

It’s important to note that specific brand names may vary depending on the country or region. 

Hexigel Brand Names in Different Countries

While Hexigel is a popular brand name for a product containing chlorhexidine gluconate, the availability and brand names of chlorhexidine-based oral gels may vary from country to country. Here are some examples of chlorhexidine-based oral gels and their brand names in different countries:

Country Brand Names
United States Peridex, PerioGard, Hibiclens
United Kingdom Corsodyl Gel, Savacol Gel
India Hexigel, Chlohex Gel, Chlorex-A Gel
Australia Savacol Gel, Chlorhexidine 1% Gel
Canada Peridex, Chlorhexidine Oral Rinse
South Africa Betadine Mouthwash and Gargle, Colgate Savacol, Hexamed
Brazil Plax Advanced, Periogard
New Zealand Savacol Gel, Chlorhexidine 1% Gel

Please note that the availability and specific brand names of chlorhexidine-based oral gels may change over time, and there may be additional brand names in each country. It is always recommended to check with local pharmacies or healthcare professionals for the most up-to-date information in 2023 on chlorhexidine-based oral gels and their brand names in your specific country.

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