Roxithromycin

Roxithromycin
4.54 ratingsReviews
Generic:
Roxithromycin
Indications:
infections
Analogs:
Azithromycin Clarithromycin Erythromycin Spiramycin Josamycin Amoxicillin Doxycycline Rulide Augmentin Levofloxacin
Roxithromycin is an oral macrolide antibiotic used in some countries to treat susceptible bacterial infections, especially respiratory tract infections.
In stock: 19 packs
AdultsPregnancyAllergiesDiabetesBreastfeedingChildrenDriving

Dosages

Roxithromycin 150 mg

Quantity Price per tablet You save Total price
60 $1.43 - $86.00
90 $1.31 $11.00 $118.00
120 $1.24 $23.00 $149.00
180 $1.18 $45.00 $213.00
270 $1.14 $80.00 $307.00
360 $1.12 $112.00 $404.00

Manufacturers

Alphapharm Pty LtdMerckle GmbHSanofi-Aventis AustraliaSanofi-Aventis Deutschland GmbHSanofi-Aventis, S.A.Sanofi S.p.A.Sanofi Winthrop Industrie

Payment & Shipping

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Shipping Times
Shipping MethodEstimated delivery
Express Free for orders over $300.00Estimated delivery to the U.S.: 4-7 days
Standard Free for orders over $200.00Estimated delivery to the U.S.: 14-21 days
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Discount Coupons

  • Independence Day - July 4, 2026 10% JULY410
  • Labor Day - September 7, 2026 7% LABOR07
  • Thanksgiving - November 26, 2026 9% THANKS09

FAQ

No. Take Roxithromycin for the full prescribed course, even if symptoms improve sooner, unless the prescriber tells you to stop. Stopping early can leave an infection incompletely treated and may allow bacteria to persist.

Roxithromycin is not FDA-approved for marketing in the United States. The exact manufacturer and regulatory status of the product supplied are not identified in the available product details, so approval cannot be assumed for a particular package.

Check the package label for "Roxithromycin," the dosage form "film-coated tablet," and the strength "150 mg." Also compare the package quantity, manufacturer name, lot number, expiration date, and tablet imprint when one is present. Do not use the tablets until a wrong ingredient, strength, dosage form, or compromised package has been clarified.

Roxithromycin is a macrolide antibiotic used to treat susceptible bacterial infections, including certain respiratory tract, urinary tract, and skin or soft-tissue infections. It does not treat viral illnesses such as colds or influenza, and the appropriate antibiotic depends on the infection and bacterial susceptibility.

Description

Note: Images in the description are provided for informational purposes and may differ from the actual appearance of the product. Please refer to the product name, strength, ingredients, and dosage form.

Roxithromycin is a macrolide antibiotic used in some countries to treat susceptible bacterial infections (most commonly respiratory tract and some skin/soft tissue infections). It is an oral, prescription-only medicine.

Roxithromycin

What it is used for

Roxithromycin may be prescribed for bacterial infections caused by susceptible organisms, including certain upper and lower respiratory tract infections and some skin/soft tissue infections. It is not effective for viral illnesses (e.g., colds or flu).

How to take

In markets where it is approved, roxithromycin is typically taken by mouth once or twice daily, often at least 15 minutes before meals (food can reduce absorption). Follow your prescriber's directions and complete the full course unless told otherwise.

Roxithromycin vs other antibiotics

Comparison Roxithromycin Amoxicillin Azithromycin Erythromycin
Drug class Macrolide Penicillin (beta-lactam) Macrolide (azalide) Macrolide
Typical role Alternative option in some countries for susceptible respiratory/skin infections Common first-line option for many ENT/respiratory infections (when appropriate) Often used for certain respiratory infections and some atypical pathogens (when appropriate) Older macrolide; still used but often limited by GI side effects and interactions
Penicillin allergy May be an alternative in some penicillin-allergic patients (clinician decision) Not suitable in true immediate-type penicillin allergy May be an alternative in some penicillin-allergic patients (clinician decision) May be an alternative in some penicillin-allergic patients (clinician decision)
Food effect Absorption can be reduced with food; often taken before meals Usually can be taken with or without food (depends on product) Depends on formulation; many can be taken with or without food Depends on salt/formulation; some have food effects
Common side effects GI upset (nausea, abdominal pain, diarrhea), headache, rash GI upset, rash; diarrhea can occur GI upset; diarrhea; often less nausea than erythromycin GI upset is common; nausea/abdominal cramps are frequent
QT/arrhythmia risk Macrolide class warning: QT prolongation can occur in rare cases Not a typical QT-prolonging antibiotic Macrolide class warning: QT prolongation can occur in rare cases Macrolide class warning: QT prolongation can occur in rare cases
Drug interaction potential Can interact with some medicines (see below); caution with anticoagulants Fewer CYP-related interactions than macrolides Generally fewer CYP3A interactions than erythromycin/clarithromycin Higher interaction burden (CYP-related) than many alternatives

When doctors usually choose which

Scenario (simplified) Often considered Notes
Typical bacterial ENT/respiratory infection where a beta-lactam is appropriate Amoxicillin Common first-line choice in many guidelines/markets; depends on diagnosis and local resistance patterns.
Suspected "atypical" respiratory pathogens, or need for a macrolide-type option Azithromycin Often preferred within the macrolide class due to convenient dosing and generally fewer CYP3A interactions than erythromycin.
Need for a macrolide alternative where available locally Roxithromycin Used in some countries; take local product info into account. In the US it is not FDA-approved.
Macrolide needed but newer alternatives are not suitable/available Erythromycin Effective in some settings, but GI side effects and interaction burden can limit use.
When to be extra cautious with macrolides Roxithromycin / Azithromycin / Erythromycin Use caution with known QT prolongation, electrolyte abnormalities, or other QT-prolonging medicines.

How it works

Roxithromycin is a macrolide antibiotic. It binds to the 50S ribosomal subunit and inhibits bacterial protein synthesis.

Side effects

Common side effects include nausea, abdominal pain, diarrhea, headache, and skin rash.

Stop the medicine and seek urgent medical care if you develop signs of a serious allergic reaction (e.g., swelling of the face/lips/tongue, difficulty breathing), severe skin reactions (blistering/peeling rash), severe or persistent diarrhea, or symptoms of liver injury (dark urine, yellowing of skin/eyes, severe fatigue).

Warnings and precautions

  • Heart rhythm: rare cases of QT prolongation and serious arrhythmias have been reported with macrolides. Use extra caution if you have known QT prolongation, low potassium/magnesium, slow heart rate, or if you take other QT-prolonging medicines.
  • Antibiotic-associated diarrhea: severe diarrhea (including C. difficile colitis) can occur during or after antibiotic therapy.
  • Liver: liver injury has been reported rarely. Use caution in severe hepatic impairment and follow clinician advice.
  • Kidney: rare cases of interstitial nephritis have been reported.

Drug-drug interactions

Tell your clinician/pharmacist about all medicines and supplements you take. Important interactions may include:

  • Warfarin and other vitamin K antagonists: increased INR and bleeding have been reported; INR monitoring is recommended during combined use.
  • Statins and fibrates: rare cases of muscle toxicity have been reported with interacting combinations; report muscle pain or weakness promptly.
  • Theophylline: exposure may increase slightly; monitoring may be needed in some patients.
  • QT-prolonging medicines: combined use can increase arrhythmia risk.

Special populations

  • Pregnancy and breastfeeding: use only if prescribed. Small amounts may pass into breast milk; discuss risks/benefits with a clinician.
  • Hepatic impairment: dose reduction may be recommended in severe hepatic impairment (clinician-directed).
  • Renal impairment: for short courses, dose adjustment is often not required; severe impairment should be clinician-managed.
  • Children: pediatric dosing is weight-based and should follow local product information and clinician guidance.

Pharmacokinetics

Roxithromycin has an absolute bioavailability of approximately 50%. Peak concentrations typically occur about 1-2 hours after dosing. Food can reduce absorption. It is highly protein-bound and distributes into tissues; small amounts may be found in breast milk. Elimination occurs via multiple routes (including fecal and urinary), with a reported half-life around 12 hours in healthy adults; the half-life may be prolonged in hepatic or renal impairment.

Off-label / investigational mentions

Some studies have explored macrolides (including roxithromycin) for conditions such as gingival overgrowth or cardiovascular prevention. These are not standard labeled indications.

Storage

Store below 25°C (77°F) in a cool, dry place. Protect from light and moisture. Keep out of reach of children.

Medically reviewed by
Donna Brettler
BPharm, MPH - Pharmacologist and medical writer
Updated August 11, 2026

Customer questions

Asked by Eric B, Denver, United States

My new Roxithromycin tablets look different from my last order. Does that mean I received the wrong medicine?

Answered by Support team

Not necessarily. Tablet color, shape, size, coating, and imprint can differ between manufacturers or batches. Before use, compare the active ingredient, 150 mg strength, film-coated tablet form, manufacturer, package label, lot number, expiration date, and any imprint; do not take it if any of those details appear incorrect or the package is damaged.

Asked by Daniel, Nashville, United States

I started Roxithromycin yesterday and now have nausea and loose stools. Are these common side effects?

Answered by Support team
Medical reviewed by Donna Brettler

Yes. Nausea, diarrhea, abdominal discomfort, and vomiting are among the more common side effects of Roxithromycin. Seek prompt medical care for severe or persistent diarrhea, bloody stools, severe abdominal pain, rash with swelling, trouble breathing, or yellowing of the skin or eyes.

Product specifications

Active ingredientRoxithromycin
Drug classMacrolide antibiotic
Dosage formFilm-coated tablet
Available strengths150 mg
Route of administrationOral
StorageStore below 77°F in a dry place, protected from moisture and light.
ATC codeJ01FA06

Regulatory information

Approval StatusRoxithromycin is not approved for human use in the United States.

More information