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Diphyllobothrium Latum Infection

Essentials of Diagnosis

  • Stool examination reveals ovoid, yellow-brown eggs (60-75 um by 40-50 um).
  • Chains of proglottids (up to 50 cm long) may be passed in stool.
  • Proglottids are wider than long (3 by 11 mm).
  • Scolex has no hooklets and two grooves (bothria).
  • Gravid proglottid contains rosette-shaped central uterus.

General Considerations

D latum is found worldwide, and infection is acquired by ingestion of contaminated raw or improperly cooked freshwater fish. Because of enthusiasm for raw or undercooked fish, Siberia, Europe, Canada, Alaska, and Japan are endemic regions for D latum infection. Once the D latum cyst has been ingested, the worm matures within the human intestine and begins to produce eggs after 5 weeks. A mature D latum may reach lengths of several meters and contain = 30,000 proglottids. Eggs and proglottids that are passed in stool hatch after 14 days in fresh water into ciliated coracidium larvae, which are ingested by the intermediate host, the aquatic copepod. Inside the copepod, the larvae develop into a second larval form, the procercoid. Once the copepod is ingested by a freshwater fish, the procercoid larva matures into the plerocercoid larva, which may encyst within fish tissues. Human ingestion of improperly prepared fish initiates infection by the plerocercoid larva cyst. Bears, seals, cats, mink, foxes, and wolves are alternate definitive hosts for D latum.

Diphyllobothrium Latum Infection

Clinical Findings

Signs and Symptoms

Infection with D latum is most often asymptomatic, but symptoms such as bloating, abdominal pain, or diarrhea may be present. More rarely, intestinal obstruction may occur. A rare complication of chronic, small-intestinal involvement with D latum is the development of Vitamin B12 deficiency, characterized by anemia with or without neurologic sequelae. This syndrome occurs most often in patients with a genetic predisposition to the development of pernicious anemia, commonly people of Scandinavia.

Laboratory Findings

Frequently the only abnormal finding in a patient infected with D latum is the presence of eggs or proglottids on examination of stool for ova and parasites. Blood examination may reveal a slight leukocytosis with eosinophilia and occasionally a megaloblastic anemia associated with B12 deficiency.


Contrast studies of the gastrointestinal tract may reveal ribbonlike filling defects corresponding to the adult worm.

Differential Diagnosis

The most usual manifestation of D latum infection is asymptomatic carriage, which is incidentally discovered. If patients present with abdominal pain and diarrhea, the differential diagnosis includes a variety of infectious and noninfectious causes. Diarrhea from D latum infection will not be associated with stool leukocytes; this aids in formulating a differential diagnosis. Noninfectious etiologies to consider include osmotic (eg, lactose intolerance) and secretory (eg, villous adenoma) etiologies, malabsorption syndromes (eg, celiac sprue), and motility disorders (eg, irritable bowel syndrome). Infectious etiologies causing diarrhea without stool leukocytes include rotavirus, Norwalk virus, Giardia lamblia, Entamoeba histolytica, Cryptosporidium spp., and toxigenic diarrhea caused by Staphylococcus aureus, Bacillus cereus, Clostridium perfringens, and enterotoxigenic Escherichia coli.


The complications vary with the clinical syndrome associated with infection. Chronic diarrhea may lead to malnutrition. Megaloblastic anemia secondary to B12 deficiency results when the parasite disrupts the B12-intrinsic factor complex, resulting in B12 becoming unavailable for absorption by the host. B12 deficiency may lead to neurologic sequelae including peripheral neuropathy, dementia, and possible severe combined degeneration of the posterior columns. Also, infection with D latum may rarely result in intestinal obstruction caused by a mass of entangled worms.


Therapy for infection with D latum consists of either praziquantel or niclosamide (Box 2). Follow-up examinations of stool should be performed 1 and 3 months after treatment.


Since the disease is not commonly associated with severe symptoms, the prognosis of infected individuals is excellent. One exception is with patients who manifest B12 deficiency, in whom the neurologic complications are reversible only if recognized and treated early.

Prevention & Control

Prevention of infection from D latum is achieved through adequate cooking of all freshwater fish or freezing of fish for 24-48 h at -18 °C (Box 3). Isolation of infected persons is not required.

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