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It is not uncommon that during some specific months of the year, people experience cold-like symptoms. Sneezing, nasal congestion, watery eyes, and a runny nose are some of them. When you or your kids exhibit such symptoms, you often wonder whether they have a connection with weather conditions.

But, commonly, this is the result of the so-called “hay fever.” These are seasonal allergies. While there are different types, seasonal allergic rhinitis has a significantly higher incidence. This occurs when spores and pollen from plants, flowers, and trees are present in the air we breathe.

In some people, these particles, referred to as allergens, trigger the immune system, which releases histamine and other chemicals. They go directly into the bloodstream. Thus, histamine is what causes the symptoms mentioned above.

To combat the effects of this substance in the body, you can use antihistamine medication. Allegra Fexofenadine is a well-known medication of this type. It effectively reduces the symptoms mentioned above in children and adults. The medical use of Allegra Fexofenadine is not limited to allergies, though. It also has an application in the treatment of urticaria and other ailments. Allegra is sold as an over-the-counter product and can be bought as a generic too.

In this article, we will review in detail everything about Allegra Fexofenadine. You will learn about its uses, recommended dose, and possible Allegra side effects. The information herein will help you decide whether this medication is adequate. If it is, you will be able to use it safely.

What Is Allegra (Fexofenadine)?

Common questions people ask are, “What is this preparation?” “What is Allegra usually used for?” Allegra is a non-drowsy (second-generation) antihistamine medication that contains the active substance Fexofenadine (C32H39NO4). This chemical compound has a molar mass of 501.667 g/mol and belongs to the group of so-called H1 blockers or H1 antagonists. Allegra Fexofenadine is highly effective in the treatment of seasonal allergy, urticaria, and other reactions of the immune system.

Fexofenadine Structure

Another common question is, “How long does Allegra normally take to work?” Roughly speaking, 30 minutes are enough for the medication to start working. Its effectiveness peaks between 1 hour and 2 hours after taking a dose. What does Allegra normally do during the time the effect lasts? In simple terms, this medication blocks the production of the histamine in the body. Hence, it alleviates the symptoms, but it does not cure the cause.

Allegra Fexofenadine can be used in both adults and children and is sold as an over-the-counter medication. This means that you can purchase it without a medical prescription. However, pediatric Allegra can be sold with a prescription only.

When you buy this medication without a prescription, you must read and understand well the directions that are included in the package. Refrain from taking the medication if you are not completely sure that you understood what the right dose for you is. If you have a doubt, you can ask the pharmacist.

Commercially, Allegra Fexofenadine is sold as tablets. These tablets can be solid or dissolving ones. More details about it are given in the next subsection. There is also an oral suspension, which is the pediatric dosage form. In most cases, a dose of this medication is taken twice a day. However, there is a medicine dosage form that is taken just once a day. It is not recommended to extend its use beyond 5 consecutive days.

The last question that people commonly ask is, “What is the best antihistamine?” or  “Is Allegra Fexofenadine the best antihistamine?” Most antihistamine medications on the market are good. They all combat the effects of histamine effectively. However, in cases in which drowsiness must be avoided, Allegra Fexofenadine is a better option.

Dosage Forms

As mentioned before, Allegra Fexofenadine is sold in 3 different dosage forms. They all can be bought in practically any pharmacy. Below you will find a more detailed description of each of these commercially available dosage forms.


Allegra Fexofenadine is available as regular tablets with 2 different concentrations of the active substance. They are sold as over-the-counter tablets with the commercial names of “12 Hour Allegra” and “24 Hour Allegra,” respectively. In both cases, the active substance is the Fexofenadine Hydrochloride.

If you pay attention, the word Hydrochloride (HCl) was added to the name of the active substance in comparison to what was mentioned before. Let us briefly explain it. Many pharmaceutical drugs are originally synthesized as either a weak acid or a base. However, in many cases, the human body cannot effectively absorb the drug in any of these forms. Poor absorption would render the medication useless since it would not have any therapeutic effect.

To overcome the problem of poor absorption, a drug in an acid or base form can be turned into a salt form. This is done through some chemical processes. A drug in a salt form can improve the dissolution of the medication too. Dissolution is the process through which the drug is released from the dosage form (a tablet, for instance) into the body.

Hence, the pure Fexofenadine is chemically converted into Fexofenadine HCl to improve its water solubility as well as bioavailability. This facilitates the absorption of the antihistamine drug in the gastrointestinal tract. This enables a quick distribution of the drug via de bloodstream.

As you can infer, the 12 Hour Allegra contains a lower amount of Fexofenadine HCl than the 24 Hour Allegra. The former contains 60 mg per tablet, whereas the latter contains 180 mg. Each tablet contains other inactive ingredients. You can read the entire list of chemical substances in each tablet on the package of this medication. 12 Hour Allegra is sold in a package with 24 tablets, whereas a package of 24 Hour Allegra contains 20 tablets.

The same concentration of 180 mg of Fexofenadine HCl is available as “24 Hour Allegra Gelcaps.” This medicine dosage form is commercially sold in a package with 24 gelcaps. The inactive ingredients are different from those of the solid tablets. Hence, to know the entire list of ingredients of this particular dosage form, you are referred to the package or the instructions therein.

Knowing the ingredients of a particular medicine preparation dosage form is important for different purposes. A physician can determine whether the medication is safe for you. He or she can determine if some chemicals in the medication could interact with other drugs that you are taking. Also, the possibility of suffering from allergic reactions or complications can be more easily assessed.

Oral suspension

Children’s Allegra is sold as an oral suspension. As mentioned, this preparation dosage is not sold if you do not produce a medical prescription. In this form, the active ingredient is the same, Fexofenadine HCl, but the concentration is lower. This medicine dosage form has a concentration of 30 mg per 5 ml. Besides the active ingredient, the suspension contains several inactive ingredients. Like in the previous cases, for the entire list of ingredients, you should read the instructions inside the package.

Oral disintegrating tablets

For children and adults alike, there is another preparation dosage form that allows easier ingestion and dissolution. This form is disintegrating tablets, which melt in the mouth. This is recommended for children that cannot swallow solid tablets. Each of these disintegrating tablets contains 30 mg of Fexofenadine HCl. This dosage form can be bought in packages with 12 disintegrating tablets.


For your safety, before taking Allegra Fexofenadine, you must be sure that you understand well how you should use it. This is particularly true if you buy it without a prescription, which is possible in all pharmacies. On the other hand, if a physician prescribes it, you must take Allegra Fexofenadine as indicated.

If you have any kidney disease, a doctor must determine whether taking Fexofenadine is safe in your particular case. It is advisable to inform about other ailments that you may have, such as diabetes. To ensure that the medication will not have any interaction, tell your physician about all other medications you are taking.

If the suspension dosage form will be given to your kid, shake the bottle vigorously first. Measure the dose in milliliters using a special tool (a measuring spoon, for example). Do not use a teaspoon or any other device that does not show whether you have the right dose. Taking a smaller dose will not have the right therapeutic effect. On the other hand, a larger dose carries the risk of overdosing.

It is advisable to take all the medical preparation dosage forms without any food. However, only the regular tablets and the suspension can be taken with food if you wish so. The disintegrating tablets must always be taken without food and on an empty stomach.

Generally, you do not need any liquids. However, if necessary, you can drink a glass of water. Refrain from using any natural or artificial juices to take this dosage form, since they could interfere with the absorption of the active ingredient.

Dosage Considerations

If a physician prescribes Allegra Fexofenadine, he or she will determine the best dose for you, depending on several factors. Your age, clinical condition, body weight, and response to Fexofenadine will be taken into account. The physician will also recommend the best dosage form for you. However, if you opt to buy Allegra Fexofenadine as over-the-counter medication, then follow the directions on the package.

For the regular 12 Hour Allegra tablets, the doses should be taken as indicated below:

  • Children +12 y.o. and adults must take 1 tablet every 12 hours (2 tablets a day);
  • Children -12 y.o. must not use this medication;
  • Adults +65 y.o. and patients with kidney problems must consult a physician to ensure that this medication is safe in their particular cases.

For the regular 24 Hour Allegra tablets, the doses should be taken as indicated below:

  • Children +12 y.o. and adults must take 1 tablet every 24 hours (1 tablet a day);
  • Children -12 y.o. must not use this medication;
  • Adults +65 y.o. and patients with kidney problems must consult a physician to ensure that this medication is safe in their particular cases.

The last directions also apply to the 24 Hour Allegra Gelcaps.

For the oral suspension, the doses should be taken as indicated below:

  • Children +12 y.o. and adults must take 10 ml every 12 hours (20 ml a day);
  • Children between 2 and 12 years of age must take 5 ml every 12 hours (10 ml a day);
  • Children -2 y.o., adults +65 y.o., and patients with kidney problems must consult a physician to ensure that this medication is safe in their particular cases.

For the orally disintegrating tablets, the doses should be taken as indicated below:

  • Children +12 y.o. and adults must take 2 tablets every 12 hours (4 tablets a day);
  • Children between 6 and 12 years of age must take 1 tablet every 12 hours (2 tablets a day);
  • Children -6 y.o., adults +65 y.o., and patients with kidney problems must consult a physician to ensure that this medication is safe in their particular cases.

The disintegrating tablets must be taken on an empty stomach.

In all cases, do not exceed or reduce the indicated dose and do not prolong the treatment for a longer period than directed. Doing so will not give better or faster results, but can be harmful to your health. By taking a higher dose, you increase the risk of suffering Allegra side effects. If, after the treatment, your condition does not improve (or worsens), immediately go to the doctor.

Before taking this medicine

Allegra Fexofenadine is a safe medication in most cases. However, to reduce the risk of Allegra side effects or a severe allergic reaction, do not take it if you are allergic to Fexofenadine. Also, consult a physician in the following cases.

Ask a doctor before use

If you suffer (or suffered) from kidney disease, you must consult a physician before taking Allegra Fexofenadine. If you are diabetic, ask the doctor if this medication is safe for you. Disintegrating tablets and oral suspension contain aspartame, which may not be suitable for diabetic patients. Also, inform the physician about all other medications that you are taking and whether you will undergo surgery soon.

If pregnant or breast-feeding

Let the physician know if you are pregnant or plan on being pregnant soon. There are some risks to the unborn baby if Allegra Fexofenadine is being taken during pregnancy. Hence, the physician will assess whether the benefits of using this medication justify the risks. Also, a physician must determine whether Allegra Fexofenadine is convenient for you if you are breast-feeding. Fexofenadine can pass to the newborn baby through breast milk.

What happens if I miss a dose

If you miss a dose, you can take it as soon as you can. However, if the next dose must be taken soon, you can skip the missed one. In most cases, adhering to a rigorous schedule is not necessary. Never double a dose to compensate for a missed one. Such an action could lead to an overdose.

What happens if I overdose

If you overdose, you must look for medical help. Go to the doctor if you have a dry mouth or feel dizzy or drowsy. Seek emergency medical help if you have problems breathing or feel like passing out. Call an emergency number or a poison control center.

How should I take Allegra?

As mentioned, in all the cases, you must strictly adhere to the doctor’s directions to take Allegra Fexofenadine. Otherwise, follow the directions on the package of the medication. Refrain from taking any antacid within 15 minutes before and after you take any of the preparation dosage forms. Such drugs can interfere with the absorption of the active ingredient. Likewise, do not drink any artificial or natural juice with Allegra Fexofenadine.

The regular tablets are taken with a glass of water. Do not drink it with any juice since this will reduce the effectiveness of the tablet. Swallow the entire tablet without chewing or biting. For the liquid medical preparation dosage form, shake the bottle before taking the dose.

The disintegrating tablets require a little bit more care to be taken. Follow these directions:

  • Do not remove the tablet from its blister until the moment you are going to take the dose;
  • When you are ready to take the dose, remove the tablet carefully to avoid damaging it. Make sure your hands are not wet to do this operation;
  • Place the tablet in your tongue. It will start disintegrating with your saliva, without the need for water;
  • Do not chew, bite, or swallow the tablet. Let it dissolve on its own;
  • Swallow as the pill is dissolving. If you deem it necessary, you can drink some water. Do not drink any other type of liquid.

Ideally, you should take Allegra Fexofenadine in this dosage form at least 1 hour before a meal. Alternatively, you can drink it after 2 hours of eating.

Side Effects

Just like any other medication, Allegra Fexofenadine can cause some unwanted effects. Some of the Allegra side effects can be mild and disappear on their own. Others, however, may need urgent medical attention.  The physician that prescribes this medication always assesses the benefits versus the risks. Hence, in most cases, you will not have any Allegra side effects.

Side effects requiring immediate medical attention

You may be experiencing some mild Allegra side effects if you:

  • Start coughing or have flu symptoms;
  • Have fever, a headache, and/or chills;
  • Have diarrhea, nausea, or any other stomach problem;
  • Are drowsy or feel tired;
  • Have menstrual cramps of back pain;
  • Have muscle pain.

There are other possible unwanted effects that may be observed, even if they are not listed above. In most cases, these effects disappear soon and do not need any medical attention. However, if these Allegra side effects do not go away after some days, you should go to the doctor. Likewise, if any of the above conditions worsen, discontinue the use of Allegra Fexofenadine and look for medical attention.

Side effects not requiring immediate medical attention

You should look for emergency medical attention if you observe some Allegra allergy side effects. Even though a serious allergic reaction (Anaphylaxis) to Fexofenadine is very uncommon, it is potentially fatal if it appears. Therefore, go to the hospital straight away if:

  • You get a rash, hives, or experience itching;
  • Cannot breathe normally;
  • Your face, lips, and/or tongue starts swelling;
  • You are seriously dizzy.

Call any emergency service if you cannot go immediately to the hospital on your own.

What other drugs will affect Allegra?

The interaction of antacids with Allegra Fexofenadine was already mentioned. To enable a thorough assessment, inform the doctor about any other drug that you may be taking. These include prescription medication, non-prescription medication, diet supplements, and herbal products. You should also inform about any recreational drug that you use regularly or occasionally.

Medications that cause sleepiness are of special interest in the assessment of possible interactions. You must tell the doctor if you take sleeping pills, pain killers, sedatives, and other similar drugs. Also, disclose whether you suffer from any mental disease and take medication for it. Likewise, you must refrain from consuming drinks with high alcohol content while you are on treatment with Allegra Fexofenadine.


Allegra Fexofenadine should always be kept out of reach of children. Store this medication in a dry place at ambient temperature between 20 °C and 25 °C (68° F to 77° F). Discard the medication if the blisters, carton, or bottle are open. Check the expiration date also. Discard all the medications that have already expired.

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