1 Star2 Stars3 Stars4 Stars5 Stars (No Ratings Yet)
Loading...

Antithyroid Drugs

Synthesis and secretion of thyroid hormones and mechanisms of action of antithyroid drugs

Synthesis and secretion of thyroid hormones and mechanisms of action of antithyroid drugs
Synthesis and secretion of thyroid hormones and mechanisms of action of antithyroid drugs

Iodine is actively concentrated by the thyroid gland (sodium iodide transporter). After oxidation it is bound to thyrosine residues thus forming monoiodothyronine (MIT) or diiodothyronine (DIT). MIT and DITare coupled to triiodothyronine (T3) orthyroxine (T4) and are stored in thyroid follicles bound to thyroglobuline. Thyroid hormones are released by proteolysis. In the peripheral blood, T4 is converted to T3. Antithyroid drugs act by inhibiting the thyroid peroxidase-mediated formation of T3 and T4 and compete with iodothyronine residues for oxidized iodine. Moreover, they inhibit iodine oxidation. Propylthiouracil (PTU), but not methyl-mercaptoimidazole (MMI), inhibits the monodeiodination of thyroxine to triiodothyronine.

Leave a Reply
  Subscribe  
Notify of