1 Star2 Stars3 Stars4 Stars5 Stars (No Ratings Yet)
Loading...

Carbapenems

Overview

Carbapenems are penicillin derivatives that have good activity against gram-positive and gram-negative aerobic and anaerobic bacteria. They are highly resistant to β-lactamase and have a very favorable spectrum of activity. A drawback of these agents is that they are available in IV form only. These agents are used in the treatment of severe, complicated acute exacerbations of chronic bronchitis when sepsis is of concern. The incidence of adverse reaction is low (1%) and occurs predominantly among the elderly or patients with predisposing central nervous system conditions. Carbapenem antibiotics include imipenem (Merck's Primaxin) meropenem (AstraZeneca's Merrem), and ertapenem (Merck's Invanz). This section reviews only imipenem/cilastatin, as this class is generally used in just a small subset of acute exacerbations of chronic bronchitis patients.

Carbapenems

Mechanism Of Action

Like the penicillins, carbapenems bind to penicillin binding proteins in bacteria and prevent bacterial cell-wall formation. By interrupting cell-wall formation, carbapenems induce cell lysis and death.

Carbapenems

Imipenem/cilastatin

Imipenem/cilastatin (Merck's Primaxin) is a prototypical carbapenem. Imipenem is coadministered with cilastatin (a peptidase inhibitor) to prevent its metabolism into nephrotoxic metabolic end products by peptidase enzymes in the body. Coadministration allows extended imipenem dosage intervals and causes less toxicity. Irnipenern/cilastatin is usually reserved for severe acute exacerbations of chronic bronchitis in the intensive care setting for patients developing sepsis. In this setting, the agent is often administered with an aminoglycoside. This agent will retain its patent protection through 2009 in the United States, but lost its patent protection in Europe and Japan in 2005.

Carbapenems

An open-label trial compared imipenem/cilastatin with meropenem (both IV) in 173 hospitalized patients with severe acute exacerbations of chronic obstructive pulmonary disease. The clinical response at the end of treatment was favorable in both groups, with a cure or improvement achieved in 97.6% of the meropenem patients and in 96.3% of the imipenem/cilastatin patients. Nausea or vomiting was reported more frequently in patients treated with imipenem/cilastatin, whereas an increase in aminotrans-ferases (indicative of liver damage) was reported in the meropenem group.

Buy Most Popular Antibiotic, Antifungal, Antiparasitic, Antiviral Drugs Online

Bactrim 400+80, 800+160 mg (Co-trimoxazole) Cipro 250, 500, 750, 1000 mg (Ciprofloxacin)
Diflucan 50, 100, 150, 200 mg (Fluconazole) Flagyl 200, 400 mg (Metronidazole)
Grifulvin 250 mg (Griseofulvin) Levaquin 250, 500, 750 mg (Levofloxacin)
Nizoral 200 mg (Ketoconazole) Sporanox 100 mg (Itraconazole)
Vermox 100 mg (Mebendazole) Amoxil 250, 500 mg (Amoxicillin)

Leave a Reply

  Subscribe  
Notify of