Author: Donna Brettler

Successful Antibiotic Desensitization

Antibiotics are often an essential component of the therapeutic plan that is developed to improve the clinical course of a patient. Typically, certain antibiotics are better for a given clinical condition. Allergies to these antibiotics, however, may limit the use of these antibiotics and in certain cases may complicate the course of optimal care. Allergies to antibiotics have become an great hindrance to the clinician.

Merrem: Carbapenem for Severe Infection

Carbapenem antibiotics were first discovered in the 1970s. The first and only marketed agent in this class was Primaxin, a combination product containing imipenem and the human renal dihyropeptidase-I (DHP-I) antagonist cilastatin.

2 Antiretroviral Drugs: Fuzeon and Reyataz

Since the introduction of zidovudine (AZT, Retrovir) in 1987, a relatively large number of drugs have been developed for the treatment of HIV-induced AIDS. Currently available antiretroviral drugs are subclassified based on their chemical structure and site of action as nucleoside reverse transcriptase inhibitors (NRTIs: zidovudine, didanosine, zalcitabine, stavudine, lamivudine and abacavir), non­nucleoside reverse transcriptase inhibitors (NNRTIs: nevirapine, delavirdine and efavirenz) and protease inhibitors (PIs: saquinavir, ritonavir, indinavir, nelfinavir, amprenavir, and lopinavir). The use of these and all antiretrovirals as monotherapy is limited largely by the rapid development of viral resistance. Thus current Public Health Service HIV treatment guidelines recommend the use of drug combinations consisting of three or four anti-AIDS drugs.

Cubicin (Daptomycin): drug for skin infections

Structure of daptomycin (trade name drug: Cubicin)

Daptomycin (Cubicin) is a cyclic lipopeptide natural product and thus represents a new structural class of antibacterial drugs with a mechanism of action that is different from those of other available antibiotics. It produces its antimicrobial effects by binding to bacterial membranes and causing a rapid depolarization of membrane potential.

Yeast infection basics

Yeast infection basics

That’s because about 75% of women will have at least 1 vaginal yeast infection during their lifetime. About half of these women have more than one. Fortunately, most yeast infections aren’t serious — especially if you get the right treatment. But symptoms of a yeast infection — which may include vaginal itching, burning, abnormal discharge — can easily be confused with those of other vaginal infections.

About Respiratory infections

About Respiratory infections

Upper respiratory infections (URIs) affect the apparatus of the upper airways, which is made up of the nose, paranasal sinuses, trachea, pharynx and larynx. Syndromes affecting these structures are sometimes associated with one another, and one upper respiratory infection can progress to another type. It can be difficult to distinguish these infections from one another because they produce similar signs and symptoms. Frequently occurring URIs include the common cold, pharyngitis, laryngitis, croup, epiglottitis and sinusitis. However, the incidence of epiglottitis has significantly decreased since the introduction of the universal Haemophilus influenzae type b (Hib) vaccine. Common Upper Respiratory Infections URI Causative Agent(s) Symptoms Treatment Common cold Rhinovirus, coronavirus, respiratory syncytial virus […]