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Buy Generic Famvir (Famciclovir) No Prescription 250mg

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Famciclovir is authorised in the world under the following brand names: Famvir.

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Famciclovir [Famvir 250mg]

Drug Approvals

(British Approved Name, US Adopted Name, rINN) INNs in other languages (French, Latin, and Spanish): Synonyms: AV-42810; BRL-42810; Famciclovir; Famciclovirum; Famciklovir; Famsikloviiri BAN: Famciclovir USAN: Famciclovir INN: Famciclovir [rINN (en)] INN: Famciclovir [rINN (es)] INN: Famciclovir [rINN (fr)] INN: Famciclovirum [rINN (la)] INN: Фамцикловир [rINN (ru)] Chemical name: 2[2-(2-Amino-9H-purin-9-yl)ethyl]trimethylene diacetate Molecular formula: C14H19N5O4 =321.3 CAS: 104227-87-4 ATC code: J05AB09; S01AD07 Read code: y01Hk Pharmacopoeias. In China.

Famciclovir

Adverse Effects and Precautions

The most common adverse effects of famciclovir are headache and nausea. Other adverse effects rarely reported include jaundice, vomiting, dizziness, skin rash, pruritus, urticaria, somnolence, confusion, and hallucinations. In addition, abdominal pain and fever have been reported in immunocompromised patients given famciclovir. Dosage should be reduced in patients with renal impairment. Acute renal failure has occurred in patients with renal impairment taking inappropriately high doses of famciclovir.

Interactions

As for Penciclovir.

Antiviral Action

As for Penciclovir.

Pharmacokinetics

Famciclovir is rapidly absorbed after oral doses. Absorption is delayed but not reduced by food. Famciclovir is rapidly converted to penciclovir, peak plasma concentrations occurring within about 1 hour of a dose, and virtually no famciclovir is detectable in the plasma or urine. Bioavailability of penciclovir is reported to be 77%. Famciclovir is mainly excreted in the urine (partly by renal tubular secretion) as penciclovir and its 6-deoxy precursor; elimination is reduced in patients with renal impairment.

Uses and Administration

Famciclovir is a prodrug of the antiviral penciclovir. It is given orally in the treatment of herpes zoster (see Varicella-zoster Infections) and genital and mucocutaneous herpes (see Herpes Simplex Infections). For herpes zoster, famciclovir is given in a dose of 250 mg three times daily, or 750 mg once daily, for 7 days (in the USA the recommended dose is 500 mg three times daily for 7 days); immunocompromised patients are given 500 mg three times daily for 10 days. For herpes simplex infections, famciclovir is given in a dose of 250 mg three times daily for 5 days for first episodes of genital herpes; immunocompromised patients are given 500 mg twice daily for 7 days. For acute treatment of recurrent episodes of genital herpes, 125 mg is given twice daily for 5 days (in the USA, the recommended dose is 1 g twice daily for 1 day). Treatment should start in the prodromal period as soon as the first signs or symptoms appear. Immunocompromised patients are given 500 mg twice daily for 7 days. For suppression of recurrent episodes of genital herpes, 250 mg is given twice daily; HIV patients may be given 500 mg twice daily. Such suppressive treatment is interrupted every 6 to 12 months to observe possible changes in the natural history of the disease. For acute treatment of recurrent mucocutaneous herpes in HIV-infected patients, 500 mg is given twice daily for 7 days. In the USA, famciclovir may also be given for the treatment of recurrent herpes labialis as a single 1.5 g dose, preferably begun in the prodromal period. Doses of famciclovir should be reduced in patients with renal impairment (see below).

Administration in renal impairment

Doses of famciclovir need to be reduced in patients with renal impairment. UK licensed product information recommends the following oral doses based on creatinine clearance (CC): Immunocompetent patients:

Herpes zoster or an initial episode of genital herpes

  • CC 30 to 59 mL/minute per 1.73 m: 250 mg twice daily
  • CC 10 to 29 mL/minute per 1.73 m: 250 mg once daily Acute recurrent genital herpes, treatment
  • CC 30 to 59 mL/minute per 1.73 m: no dosage adjustment necessary
  • CC 10 to 29 mL/minute per 1.73 m: 125 mg once daily Recurrent genital herpes, suppression
  • CC 30 mL/minute per 1.73 m and over: 250 mg twice daily
  • CC 10 to 29 mL/minute per 1.73 m: 125 mg twice daily Immunocompromised patients:

Herpes zoster

  • CC 40 mL/minute per 1.73 m and over: 500 mg three times daily
  • CC 30 to 39 mL/minute per 1.73 m: 250 mg three times daily
  • CC 10 to 29 mL/minute per 1.73 m: 125 mg three times daily

Herpes simplex infections

  • CC 40 mL/minute per 1.73 m and over: 500 mg twice daily
  • CC 30 to 39 mL/minute per 1.73 m: 250 mg twice daily
  • CC 10 to 29 mL/minute per 1.73 m: 125 mg twice daily Patients on haemodialysis should be given doses of famciclovir immediately after dialysis.

Proprietary Preparations

Argentina: Pentavir; Zosvir; Australia: Famvir; Austria: Famvir; Belgium: Famvir; Brazil: Famvir; Fanclomax; Penvir; Canada: Famvir; Czech Republic: Famvir; Denmark: Famvir; Finland: Famvir; France: Oravir; Germany: Famvir; Greece: Famvir;

Famciclovir

Hong Kong: Famvir; Hungary: Famvir; India: Famtrex; Ireland: Famvir; Israel: Famvir; Italy: Famvir; Ziravir; The Netherlands: Famvir; New Zealand: Famvir; Portugal: Famvir; Zyvir; Russia: Famvir; Singapore: Famvir; Spain: Ancivin; Famvir; Sweden: Famvir; Switzerland: Famvir; Thailand: Famvir; Turkey: Famvir; UK: Famvir; USA: Famvir

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