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Drug Nomenclature

Synonyms: Éconazole; Econazolum; Ekonatsoli; Ekonazol; Ekonazolas
BAN: Econazole
USAN: Econazole
INN: Econazole [rINN (en)]
INN: Econazol [rINN (es)]
INN: Éconazole [rINN (fr)]
INN: Econazolum [rINN (la)]
INN: Еконазол [rINN (ru)]
Chemical name: 1-[2,4-Dichloro-β-(4-chlorobenzyloxy)phenethyl]imidazole
Molecular formula: C18H15Cl3N2O =381.7
CAS: 27220-47-9
ATC code: D01AC03; G01AF05

Pharmacopoeias in Europe

European Pharmacopoeia, 6th ed. (Econazole)

A white or almost white powder. M.p. 88° to 92°. Practically insoluble in water very soluble in alcohol and in dichloromethane. Protect from light.

Econazole Nitrate

Drug Nomenclature

Synonyms: C-C2470; Econazol, nitrato de; Econazoli Nitras; Ekonatsolinitraatti; Ekonazol-nitrát; Ekonazolnitrat; Ekonazolo nitratas; R-14827; SQ-13050
BAN: Econazole Nitrate [BANM]
USAN: Econazole Nitrate
INN: Econazole Nitrate [rINNM (en)]
INN: Nitrato de econazol [rINNM (es)]
INN: Éconazole, Nitrate d’ [rINNM (fr)]
INN: Econazoli Nitras [rINNM (la)]
INN: Еконазола Нитрат [rINNM (ru)]
Chemical name: (±)-1-[2,4-Dichloro-β-(4-chlorobenzyloxy)phenethyl]imidazole nitrate
Molecular formula: C18H15Cl3N2O,HNO3 =444.7
CAS: 24169-02-6 (econazole nitrate); 68797-31-9 ((±)-econazole nitrate)
ATC code: D01AC03; G01AF05
Read code: y00UM [Gynaecological Use]; y03Dl [Skin]

Pharmacopoeias in China, Europe, and US

European Pharmacopoeia, 6th ed. (Econazole Nitrate)

A white or almost white crystalline powder. Very slightly soluble in water slightly soluble in alcohol sparingly soluble in dichloromethane soluble in methyl alcohol. Protect from light.

The United States Pharmacopeia 31, 2008 (Econazole Nitrate)

A white or practically white, crystalline powder, with not more than a slight odour. Very slightly soluble in water and in ether slightly soluble in alcohol sparingly soluble in chloroform soluble in methyl alcohol. Protect from light.

Adverse Effects and Precautions

Local reactions including burning and irritation may occur when econazole nitrate is applied topically. Contact dermatitis has been reported rarely. Intravaginal preparations of econazole may damage latex contraceptives and additional contraceptive measures are therefore necessary during local application. For a discussion of the caution needed when using azole antifungals during pregnancy, see under Pregnancy in Precautions of Fluconazole.



Econazole nitrate has been associated with acute attacks of porphyria and is considered unsafe in porphyric patients.

Antimicrobial Action

Econazole is an imidazole antifungal with antimicrobial activity similar to that of ketoconazole.


Absorption is not significant when econazole nitrate is applied to the skin or vagina.

Uses and Administration

Econazole is an imidazole antifungal used topically in the treatment of superficial candidiasis and in dermatophytosis and pityriasis versicolor (see Skin Infections). Econazole nitrate is applied topically up to 3 times daily as a 1% cream, lotion, powder, or solution in the treatment of fungal skin infections. Treatment is continued for 2 to 4 weeks. It is also used in the treatment of vaginal candidiasis as pessaries of 150 mg once daily at bedtime for 3 consecutive nights a single dose of 150 mg in a long-acting formulation has also been used. Intravaginal use of 5 g of a 1% cream once daily at night has been given for 2 weeks. A 1% cream may be used concurrently for the treatment of vulval infections or for the treatment of balanitis in a male partner. In the treatment of fungal infections of the nails, a 1% cream or lotion is applied once daily and covered with an occlusive dressing. Econazole nitrate has also been used as eye or ear drops. Econazole sulfosalicylate has also been used.


Preparations British Pharmacopoeia 2008: Econazole Cream Econazole Pessaries.

Proprietary Preparations

Argentina: Dermocitran Micocide Micofitex-H Micolis Micotex Novo Parami-con Sinamida Econazol Australia:: Dermazole Pevaryl Austria: Gyno-Pevaryl Pevaryl Belgium: Gyno-Pevaryl Pevaryl Brazil: Dermazol Micostyl Canada: Ecostatin Chile: Micolis Czech Republic: Gyno-Pevaryl Pevaryl Denmark: Pevaryl Finland: Pevaryl France: Dermazol Fongeryl Gyno-Pevaryl Mycoapaisyl Pevaryl Germany: Epi-Pevaryl Epi-Pevaryl Pv Gyno-Pevaryl Greece: Bismultin Mycobacter Nectarmicinl Penicomb Pevaryl Unifungin Hong Kong: Dermazole Econite Ecosone Gyno-Pevaryl Heads Shampoo Pevaryl Hungary: Gyno-Pevaryl Pevaryl India: Ecanol Ireland: Ecostatin Gyno-Pevaryl Pevaryl Israel: Gyno-Pevaryl Pevaryl Italy: Chemionazolo Dermazol Eccelium Eco Mi Ecodergin Ecorex Ecosteril Ganazolo Ifenec Micos Pevaryl Polinazolo Malaysia: Ecoderm Gyno-Pevaryl Pevaryl Zoliderm Mexico: Micostyl Pevaryl The Netherlands: Pevaryl Norway: Pevaryl New Zealand: Dermazole Ecreme Gyno-Pevaryl Pevaryl Philippines: Pevaryl Poland: Gyno-Pevaryl Pevaryl Pevazol Portugal: Gyno-Pevaryl Pevaryl Russia: Ecalin Ecodax Ecomikole Gyno-Pevaryl Ifenec South Africa: Ecoderm Econal-C Gyno-Pevaryl Pevaryl Singapore Dermazole Gyno-Pevaryl Pevaryl Spain: Ecotam Gyno-Pevaryl Micoespec Pevaryl Sweden: Pevaryl Switzerland: Gyno-Pevaryl Pevaryl Sebolith Thailand: Econ UK: Ecostatin Gyno-Pevaryl Pevaryl USA: Spectazole


Argentina: Diflunazol-P Filoderma Plus Griseocrem Griseo-plus Novo Bacticort Complex Austria: Pevaryl Pevisone Belgium: Pevisone Denmark: Pevisone Finland: Pevisone France: Pevisone Germany: Epi-Pevaryl Heilpaste Epipevisone Greece: Pevison Hong Kong: Pevisone Triconazole India: Cobederm-H Ecodax Israel: Pevisone Italy: Pevisone Malaysia: Ecocort Econazine Pevisone Norway: Pevisone Philippines: Nizolex Pevaryl HP Pevisone Poland: Pevisone Pont. Pevisone South Africa: Pevisone Singapore: Ecocort Econazine Pevisone Sweden: Pevisone Switzerland: Pevaryl Pevisone Thailand: Ecocort Ecoderm Pevisone Tricozole UK: Econacort.

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