Tags: Mycobutin

Antimicrobial therapy: general principles

A wide variety of antimicrobial agents is available to treat established infections caused by bacteria, fungi, viruses, or parasites. This section will cover the general principles of antimicrobial therapy and will also include illustrative clinical problems to emphasize proper decision-making in using antimicrobials.


Rifabutin, a semisynthetic spiropiperidyl derivative of rifamycin S, is an ansamycin antibiotic. The drug is active in vitro and in vivo against Mycobacterium avium complex (MAC), including isolates obtained from patients with acquired immunodeficiency syndrome (AIDS).


A common disease transmitted by inhaling airborne bacilli from a person with active tuberculosis (TB). The bacilli multiply in the alveolus and are carried by macrophages, lymphatics and blood to distant sites (eg. lung pleura, brain, kidney and bone). Tissue hypersensitivity usually halts infection within 10 weeks. Regular.