Tags: Imipenem-Cilastatin

Pseudomonas Aeruginosa

The genus Pseudomonas consists of a number of human pathogens, the most important of which is Pseudomonas aeruginosa. P aeruginosa is an opportunistic pathogen found widely in soil, water, and organic material, reflecting its limited nutritional requirements. A moist environment is favored. Human colonization in the community is rare, and, when it occurs, the skin, gut, and upper or lower airway are colonized.

Gram-Positive Aerobic Bacilli

L monocytogenes is found in soil, fertilizer, sewage, and stream water; on plants; and in the intestinal tracts of many mammals. It is a foodborne pathogen that causes bacteremic illness and meningoencephalitis, with few if any gastrointestinal manifestations.

Urinary Tract Infections and Prostatitis

A urinary tract infection is defined as the presence of microorganisms in the urine that cannot be accounted for by contamination. The organisms have the potential to invade the tissues of the urinary tract and adjacent structures.

Respiratory Tract Infections, Lower

Bronchitis, bronchiolitis, pneumonia clinical presentation and treatment.

Pneumonia – The Most Common Infectious

Pneumonia is the most common infectious cause of death in the United States. It occurs in persons of all ages, although the clinical manifestations are most severe in the very young, the elderly, and the chronically ill. The course of anaerobic pneumonia is typically indolent with cough, low-grade fever, and weight loss, although an acute presentation may occur. Putrid sputum, when present, is highly suggestive of the diagnosis.

Imipenem

Imipenem is a carbapenem beta-lactam antibacterial, differing from the penicillins in that the 5-membered ring is unsaturated and contains a carbon rather than a sulfur atom.

Merrem: Carbapenem for Severe Infection

Carbapenem antibiotics were first discovered in the 1970s. The first and only marketed agent in this class was Primaxin, a combination product containing imipenem and the human renal dihyropeptidase-I (DHP-I) antagonist cilastatin.