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Fluconazole is authorised in the world under the following brand names: Biocanol, Biozolene, Diflucan, Elazor, Flucazol, Flucostat, Flukezol, Flunizol, Flusol, Pritenzol, Triflucan.

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Fluconazole 50, 100, 150, 200 mg Tablets (Diflucan)

Fluconazole is a potent inhibitor of ergosterol biosynthesis, through its action on the cytochrome P-450-dependent enzyme, lanosterol 14a-demethylase. Depletion of ergosterol, the principal sterol in the membrane of susceptible fungal cells, and accumulation of methylated sterols leads to alterations in a number of membrane-associated cell functions. Fluconazole has a broad spectrum of action including Blastomyces dermatitidis, Coccidioides immitis, Cryptococcus neoformans, Histoplasma capsulatum and Paracoccidioides brasiliensis. It is active against Candida albicans, C. tropicalis and C. parapsilosis, but many strains of C. krusei and Torulopsis glabrata (now reclassified as Candida glabrata) appear to be insensitive.

Drug Interactions of Fluconazole 50, 100, 150, 200 mg Tablets (Diflucan)

Unlike itraconazole and ketoconazole, absorption of fluconazole is not reduced if it is given together with drugs that reduce gastric acid secretion. Concomitant administration of fluconazole and rifampicin has resulted in a modest reduction in blood levels of the antifungal agent. The effect is less marked than with itraconazole or ketoconazole and is due to induction of P-450 cytochrome oxidases by rifampicin with resulting enhanced hepatic metabolism of the azole drug. Like rifampicin, phenytoin undergoes cytochrome P-450-mediated hepatic metabolism and its concomitant administration with fluconazole may reduce its clearance.

Fluconazole 50mg, 100mg, 150mg, 200mg Capcules

Fluconazole belongs to the class of medicines called triazole derivatives, which are used to treat a variety yeast and other fungal infections (Candida and cryptococci), particularly those affecting the mouth, throat, lungs, urinary tract, blood and other organs. Fluconazole is also used to prevent fungal infections from occurring in people whose healthy defences against illness and infection are lessened (a suppressed immune system). It works by slowing the growth of fungi that cause infection.

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Fluconazole, the active ingredient, belongs to a group of medicines called anti-fungal agents and is used to treat infections caused by fungi and yeasts. The most common cause of fungal infections is yeast called Candida. Vaginal thrush is caused by tiny yeast called Candida.

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Fluconazole 50mg Capsules contain 50mg fluconazole as the active ingredient. Fluconazole 200mg Capsules contain 200mg fluconazole as the active ingredient. The capsules also contain lactose, pregelatinised maize starch, sodium laurilsulfate, colloidal anhydrous silica, magnesium stearate and purified talc.

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Fluconazole 150 is used to treat vaginal thrush (in women) and candidal balanitis (in men). Vaginal thrush is caused by a tiny yeast called Candida. Many women have the yeast living quite happily and problem-free within their bodies, but when something happens to upset the natural balance that keeps Candida under control, candidal infections occur.

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Concurrent administration of fluconazole probably causes increased exposure to amitriptyline. Three reports of adults have shown increased amitriptyline plasma concentrations with concurrent administration of fluconazole; in one patient, a 57-year-old woman, the QT interval was prolonged and torsade de pointes occurred. In vitro studies and experiments in animals have given conflicting results relating to potential antagonism between the effects of fluconazole and amphotericin on Candida species.

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In a group of children with fever, neutropenia, and neoplastic disease, there was an increase in renal fluconazole clearance. In infants and children, the volume of distribution of fluconazole is significantly higher and falls with age. With the exception of infants, who have a slower clearance rate, children clear the compound more rapidly. However, a second larger study reported slower elimination in children under 1 year of age, requiring dosage adjustments.

Dosage forms of Fluconazole:
Diflucan-dextr 200 mg/100 ml Diflucan-saline 200 mg/100 ml Co Fluconazole 50 mg Tablet Novo-Fluconazole 50 mg Tablet
Pms-Fluconazole 50 mg Tablet Apo-Fluconazole 50 mg Tablet Mylan-Fluconazole 50 mg Tablet Co Fluconazole 100 mg Tablet
Novo-Fluconazole 100 mg Tablet Pms-Fluconazole 100 mg Tablet Fluconazole 50 mg tablet Apo-Fluconazole 100 mg Tablet
Mylan-Fluconazole 100 mg Tablet Diflucan 50 mg tablet Fluconazole 100 mg tablet Apo-Fluconazole-150 150 mg Capsule
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Fluconazole 150 mg tablet Fluconazole powder Fluconazole 200 mg tablet Diflucan 150 mg Capsule
Diflucan 200 mg tablet Diflucan 150 mg tablet Fluconazole 10 mg/ml Suspension 35ml Bottle Diflucan 10 mg/ml Suspension 35ml Bottle
Fluconazole 40 mg/ml Suspension 35ml Bottle Diflucan 40 mg/ml Suspension 35ml Bottle Fluconazole-ns 200 mg/100 ml Fluconazole-dext 200 mg/100 ml
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Therapeutic classes of Fluconazole:

Antifungal Agents, Antifungals

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