Tags: Cubicin

Specific Anti-Infective Agents

Clinicians should be familiar with the general classes of antibiotics, their mechanisms of action, and their major toxicities. The differences between the specific antibiotics in each class can be subtle, often requiring the expertise of an infectious disease specialist to design the optimal anti-infective regimen. The general internist or physician-in-training should not attempt to memorize all the facts outlined here, but rather should read the pages that follow as an overview of anti-infectives. The chemistry, mechanisms of action, major toxicities, spectrum of activity, treatment indications, pharmacokinetics, dosing regimens, and cost are reviewed.

Daptomycin

Daptomycin is used for the treatment of complicated skin and skin structure infections caused by susceptible gram-positive bacteria. The drug should not be used in the treatment of pneumonia. To reduce the development of drug-resistant bacteria and maintain daptomycin efficacy, the drug should only be used to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria.

Cubicin (daptomycin) : drug for skin infections

Daptomycin (Cubicin) is a cyclic lipopeptide natural product and thus represents a new structural class of antibacterial drugs with a mechanism of action that is different from those of other available antibiotics. It produces its antimicrobial effects by binding to bacterial membranes and causing a rapid depolarization of membrane potential.