Tags: Benzylpenicillin

Penicillins: Organs and Systems: Immunologic

Anaphylactic shock can occur, even after oral administration of penicillin and skin testing. However, anaphylactic shock is less common after oral than parenteral administration. In one study the incidence of anaphylactic shock was 0.04% of all patients treated with penicillin. It is also low in patients receiving long-term benzathine penicillin (1.2 million units every 4 weeks).

Penicillins: Organs and Systems: Skin

Skin reactions are the commonest adverse effects of therapeutically administered penicillins. Penicillin-contaminated milk or meat can cause itching or generalized skin reactions or even anaphylaxis. The overall annual incidence of severe erythema multi-forme (toxic epidermal necrolysis and Stevens-Johnson syndrome) is about one case per million, antibiotics being involved in 30-40%. The clinical differentiation between these syndromes can be difficult.

Meticillin Sodium

Meticillin sodium has been reported to be incompatible with aminoglycosides and a number of other antimicrobials. It has also been reported to be incompatible with acidic and alkaline drugs. As for Benzylpenicillin. Meticillin is the penicillin most commonly associated with acute interstitial nephritis.

Flucloxacillin

Flucloxacillin is bactericidal with a mode of action similar to that of benzylpenicillin, but is resistant to sta-phylococcal penicillinase. It is active therefore against penicillinase-producing and non-penicillinase-producing staphylococci. Its activity against streptococci such as Streptococcus pneumoniae and Str. pyogenes is less than that of benzylpenicillin, but sufficient to be useful when these organisms are present with penicillin-resistant staphylococci.

Imipenem

Imipenem is a carbapenem beta-lactam antibacterial, differing from the penicillins in that the 5-membered ring is unsaturated and contains a carbon rather than a sulfur atom.

Gentamicin Sulfate

Gentamicin is an aminoglycoside antibiotic and has a bactericidal action against many Gram-negative aer-obes and against some strains of staphylococci.

Azlocillin

Azlocillin has an antimicrobial action similar to that of piperacillin. Its activity in vitro against Enterobacteriaceae is generally less than that of mezlocillin or piperacillin, but it has comparable activity to piperacillin against Pseudomonas aeruginosa.

Benzylpenicillin

The name benzylpenicillin is commonly used to describe either benzylpenicillin potassium or benzylpenicillin sodium as these are the forms in which benzylpenicillin is used. Benzylpenicillin means either the potassium or sodium salt. The potassium salt of a substance produced by growing certain strains of Penicillium notatum or related organisms or obtained by any other means. A white or almost white crystalline powder.