Combivir (Lamivudine and Zidovudine)

Combivir
4.34 ratingsReviews
Generic:
Lamivudine and Zidovudine
Analogs:
Duovir Trizivir Kivexa Epzicom Truvada Descovy Dovato Triumeq Biktarvy Genvoya Symtuza Epivir Retrovir Abacavir And Lamivudine
Combivir is a combination HIV medicine containing lamivudine and zidovudine (NRTIs). It helps reduce the amount of HIV in the body, supports immune function by increasing CD4 cells, and is taken as one tablet twice daily in adults and adolescents ≥30 kg.
In stock: 13 packs
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Dosages

Combivir 150mg+300mg

Quantity Price per tablet You save Total price
30 $1.83 - $55.00
60 $1.57 $16.10 $93.90
90 $1.42 $37.50 $127.50
120 $1.23 $72.60 $147.40
180 $1.11 $129.60 $200.40
270 $1.02 $220.70 $274.30
360 $0.92 $327.20 $332.80

Manufacturers

Apotex Inc.Cipla LimitedTeva Canada LimitedViiV Healthcare

Payment & Shipping

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Sized like a regular personal letter (9.4x4.3x0.3 inches), with no indication of what is inside.

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Shipping Times
Shipping MethodEstimated delivery
Express Free for orders over $300.00Estimated delivery to the U.S.: 4-7 days
Standard Free for orders over $200.00Estimated delivery to the U.S.: 14-21 days
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Discount Coupons

  • Independence Day - July 4, 2026 10% JULY410
  • Labor Day - September 7, 2026 7% LABOR07
  • Thanksgiving - November 26, 2026 9% THANKS09

FAQ

A prescription is required to obtain lamivudine and zidovudine from local pharmacies in the United States. Our store policy allows you to order it without a prescription and have it sent by mail.

Take the missed dose when you remember unless it is almost time for the next dose. In that case, skip the missed dose and return to the regular schedule; do not take two doses at once. Consistent dosing is important for HIV treatment, so repeated missed doses should be discussed with the clinician managing the antiretroviral regimen.

Not necessarily. A product containing lamivudine 150 mg and zidovudine 300 mg may differ from a brand-name product in color, shape, size, imprint, packaging, and inactive ingredients. Appearance alone does not determine whether a medicine has the correct active ingredients and strength.

A difference from a our product photo can occur because product appearance and packaging may vary. Check the package label for lamivudine and zidovudine tablets, the 150 mg/300 mg strength, and the dosage form. Do not use the tablets until the discrepancy is checked if the ingredient, strength, dosage form, package condition, or imprint when present appears wrong.

Keep the package and inspect the tablets and packaging before use. Store lamivudine and zidovudine tablets between 36°F and 86°F in a tightly closed container away from excess moisture.

Tablets can normally travel by mail when they are appropriately packed and protected from moisture, damage, and excessive temperatures. On arrival, inspect the package and keep the tablets in a tightly closed container within their labeled storage range of 36°F to 86°F. Do not use tablets if the package is compromised or the product appears damaged.

This product is taken orally and may be taken with or without food. The usual adult regimen for the 150 mg/300 mg tablet is one tablet twice daily as part of combination antiretroviral therapy, but the full HIV regimen and any needed dose changes must be selected for the individual. Take doses consistently and do not use this fixed-dose tablet as the only HIV medicine.

Lamivudine and zidovudine may be used during pregnancy when the expected benefit supports treatment, but pregnancy requires individualized HIV care and monitoring. Do not stop an established antiretroviral regimen without prompt medical guidance. In the United States, people with HIV are advised not to breastfeed because HIV can be transmitted through breast milk and both active ingredients pass into milk.

Common effects include headache, nausea, tiredness or malaise, diarrhea, cough, and nasal symptoms. Zidovudine can suppress bone marrow and cause anemia or low white blood cell counts, so blood counts may need monitoring. Seek urgent medical care for severe weakness, shortness of breath, unusual bleeding, fever, severe abdominal symptoms, or symptoms that could suggest lactic acidosis or liver problems.

Tell the prescriber and pharmacist about all medicines, including over-the-counter products and supplements. Medicines that can increase the risk of low blood cell counts, such as ganciclovir, valganciclovir, interferons, or some cancer treatments, need particular review. Trimethoprim-containing medicines can raise lamivudine levels, and medicines that affect zidovudine metabolism or bone marrow function may also require monitoring.

Description

Note: Images in the description are provided for informational purposes and may differ from the actual appearance of the product. Please refer to the product name, strength, ingredients, and dosage form.

What Combivir is and what it is used for

Combivir is used to treat HIV (human immunodeficiency virus) infection in adults and children.

Combivir contains two active ingredients that are used to treat HIV infection: lamivudine and zidovudine. Both of these belong to a group of anti-retroviral medicines called nucleoside analogue reverse transcriptase inhibitors (NRTIs).

Combivir

Combivir does not completely cure HIV infection; it reduces the amount of virus in your body, and keeps it at a low level. It also increases the CD4 cell count in your blood. CD4 cells are a type of white blood cells that are important in helping your body to fight infection.

Not everyone responds to treatment with Combivir in the same way. Your doctor will monitor the effectiveness of your treatment.

Before you take Combivir

Don't take Combivir:

  • if you're allergic (hypersensitive) to lamivudine or zidovudine, or any of the other ingredients of Combivir tablets (listed in section 6)
  • if you have a very low red blood cell count (anaemia) or a very low white blood cell count (neutropenia).

Check with your doctor if you think any of these apply to you.

Take special care with Combivir

Some people taking Combivir or other combination treatments for HIV are more at risk of serious side effects. You need to be aware of the extra risks:

  • if you have ever had liver disease, including hepatitis B or C (if you have hepatitis B infection, don't stop Combivir without your doctor's advice, as your hepatitis may come back)
  • if you have kidney disease
  • if you are seriously overweight (especially if you're a woman)
  • if you're diabetic and using insulin.

Talk to your doctor if any of these apply to you. Your doctor will decide if the active substances are suitable for you. You may need extra check-ups, including blood tests, while you're taking your medicine. See Section 4 for more information.

Look out for important symptoms

Some people taking medicines for HIV infection develop other conditions, which can be serious. You need to know about important signs and symptoms to look out for while you're taking Combivir.

Protect other people

HIV infection is spread by sexual contact with someone who has the infection, or by transfer of infected blood (for example, by sharing injection needles). Combivir will not stop you passing HIV infection on to other people. To protect other people from becoming infected with HIV:

Use a condom when you have oral or penetrative sex.

Don't risk blood transfer - for example, don't share needles.

Other medicines and Combivir

Tell your doctor or pharmacist if you're taking any other medicines, or if you've taken any recently, including herbal medicines or other medicines you bought without a prescription.

Remember to tell your doctor or pharmacist if you begin taking a new medicine while you're taking Combivir.

These medicines should not be used with Combivir:
  • stavudine or zalcitabine, to treat HIV infection
  • ribavirin, or injections of ganciclovir or foscarnet to treat viral infections
  • high doses of co-trimoxazole, an antibiotic.

Tell your doctor if you're being treated with any of these.

Some medicines can make it more likely that you'll have side effects, or make side effects worse.

These include:

  • sodium valproate, to treat epilepsy
  • interferon, to treat viral infections
  • pyrimethamine, to treat malaria and other parasitic infections
  • dapsone, to prevent pneumonia and treat skin infections
  • fluconazole or flucytosine, to treat fungal infections such as Candida
  • pentamidine or atovaquone to treat parasitic infections such as PCP
  • amphotericin or co-trimoxazole, to treat fungal and bacterial infections
  • probenecid, to treat gout and similar conditions, and given with some antibiotics to make them more effective
  • methadone, used as a heroin substitute
  • vincristine, vinblastine or doxorubicin, to treat cancer.

Tell your doctor if you're taking any of these.

Some medicines interact with Combivir

These include:

  • clarithromycin, an antibiotic. If you're taking clarithromycin, take your dose at least 2 hours before or after you take your Combivir.
  • phenytoin, for treating epilepsy.

Tell your doctor if you're taking phenytoin. Your doctor may need to monitor you while you're taking Combivir.

Pregnancy

If you are pregnant, if you become pregnant or if you are planning to become pregnant talk to your doctor about the risks and benefits to you and your baby of taking Combivir.

Combivir and similar medicines may cause side effects in unborn babies. If you become pregnant while you're taking Combivir, your baby may be given extra check-ups (including blood tests) to make sure it is developing normally.

Children whose mothers took NRTIs (medicines like Combivir) during pregnancy had a reduced risk of being infected with HIV. This benefit is greater than the risk of having side effects.

Breast-feeding

Women who are HIV-positive must not breast-feed, because HIV infection can be passed on to the baby in breast milk.

If you're breast-feeding or thinking about breast-feeding:

Talk to your doctor immediately.

Driving and using machines

Combivir can make you dizzy and have other side effects that make you less alert. Don't drive or operate machines unless you're feeling well.

How to take Combivir

Always take Combivir exactly as your doctor has told you to. Check with your doctor or pharmacist if you're not sure.

Swallow Combivir tablets, with some water. Combivir can be taken with or without food.

If you cannot swallow the tablets whole, you may crush and combine them with a small amount of food or drink, and take all the dose immediately.

Stay in regular contact with your doctor.

Combivir helps to control your condition. You need to keep taking it every day to stop your illness getting worse. You may still develop other infections and illnesses linked to HIV infection.

Keep in touch with your doctor, and don't stop taking Combivir without your doctor's advice.

How much to take

Adults and adolescents 30 kg or more

The usual dose of Combivir is one tablet twice a day.

Take the tablets at regular times, leaving approximately 12 hours between each tablet.

Children who weigh between 21 and 30 kg

The usual starting dose of Combivir is one half tablet taken in the morning and one whole tablet taken in the evening.

Children who weigh between 14 and 21 kg

The usual starting dose of Combivir is one half tablet taken in the morning and one half tablet taken in the evening.

For children who weigh less than 14 kg lamivudine and zidovudine (the ingredients of Combivir) should be taken separately.

If you take too much Combivir

If you accidentally take too much Combivir, tell your doctor or your pharmacist, or contact your nearest hospital emergency department for further advice.

If you forget to take Combivir

If you forget to take a dose, take it as soon as you remember. Then continue your treatment as before. Don't take a double dose to make up for a missed dose.

Possible side effects

Like all medicines, Combivir can cause side effects, but not everyone gets them.

When you're being treated for HIV, it can be hard to tell whether a symptom is a side effect of Combivir or other medicines you're taking, or an effect of the HIV disease itself. So it is very important to talk to your doctor about any changes in your health.

As well as the side effects listed below for Combivir, other conditions can develop during combination therapy for HIV. It is important to read the information later in this section under 'Other possible side effects of combination therapy for HIV.'

Very common side effects

These may affect more than 1 in 10 people:

  • headache
  • feeling sick (nausea).

Common side effects

These may affect up to 1 in 10 people:

  • being sick (vomiting)
  • diarrhoea
  • stomach pains
  • loss of appetite
  • feeling dizzy
  • tiredness, lack of energy
  • fever (high temperature)
  • general feeling of being unwell
  • difficulty in sleeping (insomnia)
  • muscle pain and discomfort
  • joint pain
  • cough
  • irritated or runny nose
  • skin rash
  • hair loss (alopecia).

Common side effects that might show up in blood tests are:

  • a low red blood cell count (anaemia) or low white blood cell count (neutropenia or leucopenia)
  • an increase in the level of liver enzymes
  • an increased amount in the blood of bilirubin (a substance produced in the liver) which may make your skin appear yellow.

Uncommon side effects

These may affect up to 1 in 100 people:

  • feeling breathless
  • wind (flatulence)
  • itching
  • muscle weakness.

An uncommon side effect that may show up in blood test is:

  • a decrease in the number of cells involved in blood clotting (thrombocytopenia) or in all kinds of blood cells (pancytopenia).

Rare side effects

These may affect up to 1 in 1000 people:

  • serious allergic reaction causing swelling of the face, tongue or throat which may cause difficulty in swallowing or breathing
  • liver disorders, such as jaundice, enlarged liver or fatty liver, inflammation (hepatitis)
  • lactic acidosis (see the next section, 'Other possible side effects of combination therapy for HIV')
  • inflammation of the pancreas (pancreatitis)
  • chest pain; disease of the heart muscle (cardiomyopathy)
  • fits (convulsions)
  • feeling depressed or anxious, not being able to concentrate, feeling drowsy
  • indigestion, taste disturbance
  • changes in the colour of your nails, your skin or the skin inside your mouth
  • a flu-like feeling - chills and sweating
  • tingly feelings in the skin (pins and needles)
  • sensation of weakness in the limbs
  • breakdown of muscle tissue
  • numbness
  • passing urine more often
  • enlarged breasts in men.

Rare side effects that may show up in blood tests are:

  • an increase in an enzyme called amylase
  • a failure of the bone marrow to produce new red blood cells (pure red cell aplasia).

Very rare side effects

These may affect up to 1 in 10,000 people:

A very rare side effect that may show up in blood tests is:

  • a failure of the bone marrow to produce new red or white blood cells (aplastic anaemia).

If you get side effects

Tell your doctor or pharmacist if any of the side effects get severe or troublesome, or if you notice any side effects not listed in this leaflet.

Other possible side effects of combination therapy for HIV

Combination therapy such as Combivir may cause other conditions to develop during HIV treatment.

Old infections may flare up

People with advanced HIV infection (AIDS) have weak immune systems, and are more likely to develop serious infections (opportunistic infections). When these people start treatment, they may find that old, hidden infections flare up, causing signs and symptoms of inflammation. These symptoms are probably caused by the body's immune system becoming stronger, so that the body starts to fight these infections. If you get any symptoms of infection while you're taking Combivir:

Tell your doctor immediately. Don't take other medicines for the infection without your doctor's advice.

Your body shape may change

People taking combination therapy for HIV may find that their body shape changes, because of changes in fat distribution:

Fat may be lost from the legs, arms or face.

Extra fat may build up around the tummy (abdomen), or on the breasts or internal organs.

Fatty lumps (sometimes called buffalo hump) may appear on the back of the neck.

It is not yet known what causes these changes, or whether they have any long-term effects on your health. If you notice changes in your body shape: tell your doctor.

Lactic acidosis is a rare but serious side effect

Some people taking Combivir, or other medicines like it (NRTIs), develop a condition called lactic acidosis, together with an enlarged liver.

Lactic acidosis is caused by a build up of lactic acid in the body. It is rare; if it happens, it usually develops after a few months of treatment. It can be life-threatening, causing failure of internal organs. Lactic acidosis is more likely to develop in people who have liver disease, or in obese (very overweight) people, especially women.

Signs of lactic acidosis include:

  • deep, rapid, difficult breathing
  • drowsiness
  • numbness or weakness in the limbs
  • feeling sick (nausea), being sick (vomiting)
  • stomach pain.

During your treatment, your doctor will monitor you for signs of lactic acidosis. If you have any of the symptoms listed above, or any other symptoms that worry you:

See your doctor as soon as possible.

You may have problems with your bones

Some people taking combination therapy for HIV develop a condition called osteonecrosis. With this condition, parts of the bone tissue die because of reduced blood supply to the bone. People may be more likely to get this condition:

  • if they have been taking combination therapy for a long time
  • if they are also taking anti-inflammatory medicines called corticosteroids
  • if they drink alcohol
  • if their immune systems are very weak
  • if they are overweight.

Signs of osteonecrosis include:

  • stiffness in the joints
  • aches and pains (especially in the hip, knee or shoulder)
  • difficulty moving.

If you notice any of these symptoms: tell your doctor.

Other effects may show up in blood tests

Combination therapy for HIV can also cause:

  1. increased levels of lactic acid in the blood, which on rare occasions can lead to lactic acidosis
  2. increased levels of sugar and fats (triglycerides and cholesterol) in the blood
  3. resistance to insulin (so if you're diabetic, you may have to change your insulin dose to control your blood sugar).

How to store Combivir

Keep Combivir out of the reach and sight of children.

Do not take Combivir after the expiry date shown on the carton.

Do not store above 30°C.

If you have any unwanted Combivir tablets, don't dispose of them in your waste water or your household rubbish. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.

Further information

What Combivir contains

The active substances are lamivudine and zidovudine. The other ingredients are:

  • tablet core: microcrystalline cellulose, sodium starch glycollate (gluten free), magnesium stearate, colloidal silicon dioxide
  • tablet film-coat: hypromellose, titanium dioxide, macrogol 400 and polysorbate 80.

What Combivir looks like and contents of the pack

Combivir film-coated tablets are provided in tamper evident blister packs containing 60 tablets. They are white to off-white, capsule-shaped scored tablets marked with the code GXFC3 on both sides.

Medically reviewed by
Brian Holtry
MD, infectious diseases specialist and medical writer
Updated August 11, 2026

Customer questions

Asked by Michael, New York, United States

If I place another order later, will my lamivudine and zidovudine tablets come from the same manufacturer as my first order?

Answered by Support team

We cannot guarantee the same manufacturer for every order. When your package arrives, verify the active ingredients, 150 mg/300 mg strength, tablet dosage form, manufacturer, lot number, expiration date, and imprint if one is present.

Asked by Danielle, Seattle, United States

I live in Seattle. Can I check whether lamivudine and zidovudine can be shipped to my ZIP code before I order?

Answered by Support team

Yes. Enter your Seattle ZIP code during checkout to see whether the product is available for shipment to your address. Availability can vary by destination, so checkout provides the current result.

Asked by Carlos, Dallas, United States

My order arrived today. Where on the package can I confirm that I received lamivudine and zidovudine 150 mg/300 mg tablets?

Answered by Support team

Check the medicine package label for the active ingredients "lamivudine and zidovudine," the strength "150 mg/300 mg," and "tablet" as the dosage form. Also compare the manufacturer, lot number, expiration date, and tablet imprint if present; do not take the medicine if an identifier does not match what you ordered.

Asked by Erica, Houston, United States

I have reduced kidney function and take several medicines. Is the fixed-dose lamivudine and zidovudine tablet appropriate for me?

Answered by Support team
Medical reviewed by Brian Holtry

Reduced kidney function can require adjustment of lamivudine dosing, which cannot be done with this fixed-dose tablet. A clinician should review your kidney function and complete medication list before determining whether separate components or another regimen is needed.

Product specifications

Active ingredientLamivudine and zidovudine
Drug classAntiretroviral combination of nucleoside reverse transcriptase inhibitors (NRTIs)
Dosage formTablet
Available strengths150 mg/300 mg
RouteOral
StorageStore between 36°F and 86°F in a tightly closed container, away from excess moisture.
ATC codeJ05AR01

Regulatory information

Approval StatusThe combination of lamivudine and zidovudine is approved for human medical use in the United States.
Prescription RequirementA valid prescription from a licensed healthcare provider is required to dispense these tablets.

More information