Drug Guide

Management of Malaria

Malaria is a protozoan (genus Plasmodium) infection transmitted by the bite of an infected female Anopheles mosquito and rarely via a contaminated blood transfusion. It is extremely common, affecting more than 500 million persons and resulting in more than 1 million deaths each year. There are four species of the genus Plasmodium that cause malaria in man.

Erythrocytic asexual phase

This begins with penetration into red blood cells by merozoites arising from the exoerythrocytic schizonts in the liver cells. The parasites grow rapidly, and a large central vacuole forms in the cytoplasm leading to the so-called ring form.

Evaluation of the efficacy of vaccines

Adequate response to immunization is most frequently judged by measuring the development of specific serum immunoglobulins (e.g., antibodies) following a course of administration of vaccine. The concentration of specific immunoglobulin in plasma is usually proportional to the degree of protection from the viral agent.


Penicillin G is an acid that is combined with sodium, potassium, procaine, or benzathine to increase its stability or to regulate its absorption. The latter two are “long-acting” forms. Penicillin G is useful in the treatment of streptococcal infections due to S. pyogenes (group A), S. agalactiae (group B), S. pneumoniae, viridans streptococci, Corynebacterium diphtheria, N. meningitidis, many strains of N. gonorrhea, Treponema pallidum, and many anaerobic streptococci, such as peptococcus and peptostreptococcus.

Aminoglycosides – antibiotic agents

Aminoglycosides are very potent bactericidal antibiotic agents that are active against susceptible aerobic microorganisms. They kill by inhibiting protein synthesis and to some extent by lysing the cell envelope. All the aminoglycosides (streptomycin, kanamycin, neomycin, gentamicin, amikacin, tobramycin, sisomicin, and netilmicin) share common structural features. Streptomycin is used once a day in combination with other antibiotics to treat mycobacterial infections.

Vancomycin Glycopeptides

Vancomycin and teicoplanin are the only members of this class of antibiotics. Vancomycin is a high-molecular-weight glycopeptide that is bactericidal for gram-positive microorganisms. It inhibits cell-wall synthesis. Given parenterally, it is the drug of choice for methicillin-resistant staphylococcal infections.

Order Griseofulvin (Grifulvin) Without Prescription 250mg

Griseofulvin is used in the treatment of tineas (ringworm infections) of the skin, hair, and nails, including tinea barbae, tinea capitis, tinea corporis, tinea cruris, tinea pedis, and tinea unguium (onychomycosis) caused by susceptible species of Trichophyton, Microsporum, or Epidermophyton. Because the drug is not effective against other fungal infections, the infecting organism should be identified as a dermatophyte before initiating therapy.

Buy Co-trimoxazole (Bactrim) 400/800mg No Prescription

The most frequent adverse effects of co-trimoxazole are adverse GI effects (nausea, vomiting, anorexia) and sensitivity skin reactions (e.g., rash, urticaria), each reportedly occurring in about 3.5% of patients. The incidence and severity of these adverse reactions are generally dose related, and adverse reactions may occasionally be obviated by a reduction in dosage. Hypersensitivity and hematologic reactions are the most serious adverse effects of co-trimoxazole, reportedly occurring in less than 0.5% of patients.

Order Bactrim (Co-trimoxazole) No Prescription 400/800mg

Co-trimoxazole (Bactrim 400+80mg, 800+160mg Tablets) is administered orally or by IV infusion. When oral therapy is not feasible or for severe infections, the drug may be administered IV. The drug should not be injected IM. Co-trimoxazole for injection concentrate must be diluted prior to IV infusion.