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Order No Prescription Clotrimazole (Gyne-Lotrimin) Antifungal Cream 15g

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Clotrimazole [Lotrimin 15g]

Drug Nomenclature

International Nonproprietary Names (INNs) in main languages (French, Latin, and Spanish):

Synonyms: Bay-5097; Clotrimazol; Clotrimazolum; FB-5097; Klotrimatsoli; Klotrimazol; Klotrimazolas
BAN: Clotrimazole
USAN: Clotrimazole
INN: Clotrimazole [rINN (en)]
INN: Clotrimazol [rINN (es)]
INN: Clotrimazole [rINN (fr)]
INN: Clotrimazolum [rINN (la)]
INN: Клотримазол [rINN (ru)]
Chemical name: 1-(α-2-Chlorotrityl)imidazole
Molecular formula: C22H17ClN2 =344.8
CAS: 23593-75-1
ATC code: A01AB18; D01AC01; G01AF02
Read code: y00o9 [Ear]; y08EL [Skin]; y03Dg

Note. Compounded preparations of clotrimazole may be represented by the following names:

  • Co-climasone (PEN) — clotrimazole and betamethasone di-propionate.

Pharmacopoeias in China, Europe, Japan, and US

Clotrimazole (Gyne-Lotrimin) Antifungal Cream 15g

European Pharmacopoeia, 6th ed. (Clotrimazole)

A white or pale yellow crystalline powder. Practically insoluble in water soluble in alcohol and in dichloromethane. Protect from light.

The United States Pharmacopeia 31, 2008 (Clotrimazole)

A white to pale yellow, crystalline powder. Practically insoluble in water freely soluble in alcohol, in acetone, in chloroform, and in methyl alcohol. Store in airtight containers.

Adverse Effects and Precautions

Nausea, vomiting, unpleasant mouth sensations, and pruritus have been reported after the use of oral clotrimazole lozenges.

Raised liver enzyme values have also occurred. Local reactions including irritation and a burning sensation may occur in patients treated topically contact allergic dermatitis has been reported. Intravaginal preparations of clotrimazole may damage latex contraceptives and additional contraceptive measures are therefore necessary during local application.

Gastrointestinal disturbance, elevation of liver enzymes, dysuria, and mental depression have been reported after oral clotrimazole (although this route is no longer used).

Clotrimazole (Gyne-Lotrimin) Antifungal Cream 15g

For a discussion of the caution needed when using azole antifungals during pregnancy, see under Pregnancy in Precautions of Fluconazole.

Antimicrobial Action

Clotrimazole is an imidazole antifungal with antimicrobial activity similar to that of ketoconazole.


When applied topically clotrimazole penetrates the epidermis but there is little i any systemic absorption. Absorption of 3 to 10% of a dose has been reported after vaginal use. Clotrimazole is metabolised in the liver to inactive compounds and excreted in the faeces and urine.

Uses and Administration

Clotrimazole is an imidazole antifungal used topically in superficial candidiasis, and in the skin infections pityriasis versicolor and dermatophytosis (see Skin Infections). Clotrimazole may also be used occasionally for symptomatic relie of the protozoal infection trichomoniasis when other drugs are contra-indicated.

Clotrimazole is applied topically two or three times daily for 2 to 4 weeks as a 1% cream, lotion, spray, or solution in the treatment of fungal skin infections a 1% powder may be used with the cream or solution and has been applied to prevent re-infection. The 1% solution is also used topically for fungal otitis externa.

Clotrimazole is given as pessaries in dosage regimens of 100 mg for 6 days, 200 mg for 3 days, or a single dose of 500 mg in the treatment of vulvovaginal candidiasis; similar doses are given as a 1, 2, or 10% vaginal cream. It may be necessary to treat balanitis in male partners concurrently.

For the treatment of oropharyngeal candidiasis one 10-mg lozenge of clotrimazole is dissolved in the mouth five times daily for 14 days.

For the prophylaxis of oropharyngeal candidiasis in patients receiving immu-nosuppressant therapy the dose is one 10-mg lozenge three times daily for the duration of the immunosup-pressant treatment. Clotrimazole has also been given orally but has now been largely superseded by other azole drugs.

Sickle-cell disease

Oral clotrimazole has been investigated for the treatment of sickle-cell disease.

Clotrimazole (Gyne-Lotrimin) Antifungal Cream 15g


British Pharmacopoeia 2008: Clotrimazole Cream Clotrimazole Pessaries

Clotrimazole (Gyne-Lotrimin) Antifungal Cream 15g

The United States Pharmacopeia 31, 2008: Clotrimazole and Betamethasone Dipropionate Cream Clotrimazole Cream Clotrimazole Lotion Clotrimazole Lozenges Clotrimazole Topical Solution Clotrimazole Vaginal Tablets.

Proprietary Preparations

Argentina: Aflorix Clotri-Q Clotrix Empecid Eximius Ikolan Klomazole Livomonil Medifungol Micoclin Micomax Micomazol Micomazol Deo Mi-cosep Micosep B Micotrim Mycanden Panmicol Sinfung Trimazol Australia: Canesten Chemists Own Clozole Clofeme Clonea Clotreme Femizol Gyne-Lotrimin Tinaderm Extra Topizol Austria: Candibene Canesten Myko Cordes Pedikurol Belgium: Canestene Gyno-Canestene Brazil: Antimicotico Martel Canesten Clomazen Clomazol Clotigen Clotren Clotriderm Clotrimix Clotrizan Dermobene Gino-Canesten Gino-Clotrimix Kinasten Miclonazol Micosten Micotrat Micotrizol Neo Clotrimazyl Canada: Canesten Clotrimaderm Chile: Arnela Axasol Canesten Cestop Clotrimin Cotrisan Creminem Funzal Gynocanesten Konifungil Laboterol Novacetol Telugren Czech Republic: Aknecolor Baycuten Candibene Canesten Canifug Imazol Jenamazol Plimycol Denmark: Canesten Finland: Canesten Germany: Antifungol Aru C Azutrimazol Benzoderm Mycof Candazol Canesten Canifug Cloderm Clotrigalen cutistad du-rafungol Fungiderm Fungizid Gilt Gyno-Canesten Holfungin Jenamazol KadeFungin Mycofug Myko Cordes Mykofungin Mykohaug Ovis Neu SD-Hermal Uromykol Greece: Canesten Factodin Hong Kong: Aristen Canesten Clocreme Clotri-Denk Clozole Cotren Fungizid Gyne-Lotremin Kamicin Lotremin Mycoril Tricloderm Warimazol Hungary: Candibene Canesten Canifug India: Candid Clocip Clozol Imidil Mycocid Mycoderm-C Surfaz Indonesia: Bernesten Canesten Clonitia Fungiderm Gyne-Lotremin Kranos Lotremin Medisten Trimadan Ireland: Canesten Israel: Agisten Baby Agisten Clotrimaderm Myco-Hermal Oralten Troche Italy: Antimicotico Canesten Gyno-Canesten Malaysia: Candazole Candid Canesten Clomazole Cotren Fungicip Gyne-Lotremin Gynostatum Loriderm Lotremin Micoter Trimazol Mexico: Altenal Baycuten Candimon Candiphen Canesten Cinabel Clocan Clomacin Dermasten Euroderm Liferzol Lomecan V Lonestin Lotrimin Tenescan The Netherlands: Canesten Parvemaxol Norway: Canesten New Zealand: Canesten Clocreme Clomazol Clotrihexal Clotrimaderm Philippines: Candid V6 Canesten Cloxy Gixaderm Gynesol Vaf Poland: Canesten Portugal: Candid Canesten Diomicete Gino-Canesten Gino-Lotremine Lotremine Micolysin Nalbix Pan-Fungex Russia: Amyclon Antifungol Candibene Candid Candid V6 Canesten South Africa: A-Por Canalba Candaspor Candizole Canesten Canex Closcript Covospor Fungispor Gyno-Trimaze Medaspor Micomisan Mycoban Mycohexal Normospor Stiemazol Trimaze Xeraspor Singapore: Candazole Canesten Cotren Cristan Gyne-Lotremin Lotremin Myco-Hermal Mycoril Sastid Anti-Fungal Vanesten Spain: Canesten Fungidermo Gine Canesten Sweden: Canesten Switzerland: Acnecolor Canestene Corisol Eurosan Fungotox Gromazol Gyno-Canestene Imazol Undex Thailand: Caginal Canadine Canazol Candazole Candid Candinox Canesten Chingazol Clotri Clotricin Comat Cotren CST Defungo Dermaten Fango Cream Fungicon Fungiderm Gynebo Kanezin Klamacin Manomazole Mycoderm-C Mycozole Nestic Taraten Vamazole Vanesten Zema Turkey: Canesten Clozol Fungosten Gyno-Canesten UK: Abtrim Candiden Canesten Canesten Combi Fungederm Privacom USA: Gyne-Lotrimin Lotrimin Lotrimin A Mycelex Mycelex-7 Venezuela: Canesten Clortilen Clotrizol Fugolin Ginolotricomb Gyno Canesten Imazol Ipalat Lecibis Micozol Oxisol Polik


Argentina: Becortin Calmurid Cortispec Dermovit Empecid Cort Hongal Lotricomb Micomazol B Quaclriderm Quiacort G Plus Vagarne Vagisan Compuesto Vitacortil Australia: Canesoral Duo Hydrozole Austria: Myko Cordes Belgium: Lotriderm Brazil: Baycuten Canada: Lotriderm Chile: B-Laboterol Baycuten Cestop B Clotrimin-B Creminem-B Cutanil Donomix Locrim Lotriderm Novadrel Novarnela Telugren Plus Tribesona Czech Republic: Imacort Imazol Plus Lotriderm Denmark: Clotrason France: Triazol Germany: Antifungol Baycuten HC Baycuten Canesten HC Fungidexan Imazol Imazol comp Lotricomb Myko Cordes Plus Hong Kong: Becogem Canesten HC Clobeta-G Clotrinolon Derzid-C Lozopin Synco-CFN Triderm India: Candibiotic Candid B Candid Ear Drops Candid-TV Candiderma + Candiderma Cloben-G Clocip B Clocip NB Clomycin Cutinorm Fourderm A NC-Derm Neocip FC Otek-AC+ Sigmaderm Sofradex Surfaz Surfaz-SN Translipo-Triple Indonesia: Baycuten-N Heltiskin Lotriderm Ireland: Canesten HC Lotriderm Israel: Agisten with Aloe Vera Clotrisone Hydroagisten Polycutan Tevacutan Triderm Italy: Desamix Effe Meclon Malaysia: Baycuten N Betamethasone Go Candacort Triderm-C Mexico: Barmicil Compuesto Baycuten N Beclogen Betrigen Clotricina Gelmicin Miclobet Prubagen Quadriderm N Triderm Xyloderm New Zealand: Lotricomb Philippines: Baycuten Candibec Clotrasone Triderm Poland: Lotriderm Triderm Portugal: Baycuten Beta-Micoter Flotiran Quadriderme Russia: Akriderm GK Candibiotic Candid B Metrogyl Plus Triderm South Africa: Lotriderm Singapore Candacort Canesten HC Clotrasone Combiderm Gentriderm Gentrisone Modaderm Neoderm Triderm Spain: Beta Micoter Clotrasone Switzerland: Imacort Imazol Triderm Thailand: Bacda-B Canasone Canazol-BE Candacort Clotrasone Derzid-C Fango-B Fungicon Fungiderm-B Gynesten-B Gynestin Mycla-B Myrazole-B Twina Turkey: Imazol UK: Canesten HC USA: Lotrisone Venezuela: Baycuten N Lotricomb Lotrisone Triderm. The symbol denotes a preparation no longer actively marketed.

Dosage forms of Clotrimazole:
Gyne-lotrimin insert Lotrimin 1% cream Mycelex-7 100 mg vaginal tablet Clotrimazole 10 mg troche
Mycelex 10 mg troche Clotrimazole powder Clotrimazole 1% Cream 15 gm Tube Clotrimazole 1% Solution 10ml Bottle
Clotrimazole 1% Solution 30ml Bottle Clotrimazole 1% Cream 30 gm Tube Clotrimazole 1% Cream 45 gm Tube Clotrimazole 70 10 mg Troche Bottle
Lotrimin af 2% liquid spray Lotrimin af 2% spray powder Clotrim 1% vaginal cream Ra clotrimazole af cream
Sm antifungal 1% cream Antifungal 1% cream CVS Pharmacy clotrimazole 1% cream Desenex 1% cream
Ra athlete’s 1% foot cream Ra clotrimazole 3 cream Clotrimazole 3 2% cream Clotrimazole 1% cream
Lotrimin ultra 1% cream Clotrimazole insert Mycelex 1% cream  

Synonyms of Clotrimazole:

Chlotrimazole, Clotrimazol

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Therapeutic classes of Clotrimazole:

Anti-Infective Agents, Local, Antifungal Agents, Growth Inhibitors


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