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Ribavirin is authorised in the world under the following brand names: Copegus, Rebetol, Rebetron, Rebretron, Ribamide, Ribamidil, Ribamidyl, Ribasphere, RIBAV, Ribavirin Capsules, Ribavirin-TP, RTC, RTCA, RTP, Tribavirin, Varazid, Vilona, Viramid, Virazid, Virazole, Virazole 5′-triphosphate.

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The synthetic triazole nucleoside, ribavirin (1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide, tribavirin, virazole), has a broad spectrum of antiviral activity, including DNA as well as RNA viruses. Ribavirin closely resembles guanosine and is converted intracellularly to mono-, di-, and triphosphate derivatives, which inhibit the virally induced enzymes involved in viral nucleic acid synthesis by different mechanisms that are not fully understood. Of the DNA viruses, ribavirin is active against Herpes simplex virus and hepatitis B virus; among the RNA viruses, good activity has been observed against hepatitis C virus, orthomyxoviruses, paramyxoviruses, arenaviruses, and bunyaviruses.

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Ribavirin accumulates in erythrocytes, resulting in hemolysis by an unknown mechanism, perhaps related to oxidative damage to the erythrocyte membrane. Time-dependent and dose-dependent hemolytic anemia (eventually associated with hyperbilirubinemia and a high reticulocyte count) is the only major toxic effect associated with oral or intravenous ribavirin and is reversible on withdrawal.

Anti-Infective Therapy

Despite dire warnings that we are approaching the end of the antibiotic era, the incidence of antibiotic-resistant bacteria continues to rise. The proportions of penicillin-resistant Streptococcus pneumoniae, hospital-acquired methicillin-resistant Staphylococcus aureus, and vancomycin-resistant Enterococcus strains continue to increase. Community-acquired methicillin-resistant Staphylococcus aureus is now common throughout the world.

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Ribavirin is indicated in the treatment of carefully selected hospitalized infants and young children with severe lower respiratory tract infections due to respiratory syncytial virus (RSV). In addition, ribavirin (600 to 1800 mg / day for 10 to 14 days) has shown effectiveness in acute and chronic hepatitis, herpes genitalis, measles, and Lassa fever. The antiviral mechanism of action of ribavirin relates to alteration of cellular nucleotide pools and inhibition of viral messenger RNA synthesis. Intracellular phosphorylation to the mono-, di-, and triphosphate derivatives is mediated by host cell enzymes.

Dosage forms of Ribavirin:
Rebetol 40 mg/ml Solution Ribavirin powder Ribasphere 200 mg tablet Ribavirin 200 mg tablet
Ribasphere 200 mg capsule Ribavirin 200 mg capsule Rebetol 200 mg capsule Copegus 200 mg tablet
Ribasphere 400 mg tablet Ribavirin 400 mg tablet Ribavirin 500 mg tablet Ribatab 400 mg tablet
Ribasphere 600 mg tablet Ribavirin 600 mg tablet Ribatab 600 mg tablet Virazole 6 gm vial

Synonyms of Ribavirin:

RBV, Ribavirin Triphosphate, Ribavirina [INN-Spanish], Ribavirine [INN-French], Ribavirinum [INN-Latin]

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Therapeutic classes of Ribavirin:

Antimetabolites, Antiviral Agents


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