Tags: Nydrazid

Pulmonary Infections

Acute pneumonia is a potentially life-threatening illness requiring rapid diagnosis and treatment. A delay in antibiotic treatment increases the risk of a fatal outcome. Annually, 2 to 3 million cases of pneumonia are reported in the United States.

Antimicrobial therapy: general principles

A wide variety of antimicrobial agents is available to treat established infections caused by bacteria, fungi, viruses, or parasites. This section will cover the general principles of antimicrobial therapy and will also include illustrative clinical problems to emphasize proper decision-making in using antimicrobials.

Isoniazid – Antituberculosis Agent

Isoniazid usually is administered orally. The drug may be given by IM injection when oral therapy is not possible. The fixed-combination preparation containing isoniazid and rifampin (RifamateĀ®) and the fixed-combination preparation containing isoniazid, rifampin, and pyrazinamide (RifaterĀ®) should be given either 1 hour before or 2 hours after a meal; the manufacturer states that RifaterĀ® should be given with a full glass of water.


Isoniazid is a hydrazide derivative that is the mainstay of the primary treatment of pulmonary and extrapulmonary tuberculosis. It is used with other antituberculous drugs usually in regimens including rifampicin, ethambutol, and pyrazinamide. Isoniazid is also used in high-risk subjects for the prophylaxis of tuberculosis. Isoniazid is given in the initial and continuation phases of short-course tuberculosis regimens.