Tags: Melioidosis

Other Pseudomonas Species of Medical Importance

This organism is endemic in Southeast Asia with the highest prevalence in Thailand. The organism is a saprophyte living in the soil. Infection may be subclinical, acute, subacute, or chronic.

Infectious disorders

Infectious diseases comprise those illnesses that are caused by microorganisms or their products. Clinical manifestations of infection occur only when sufficient tissue injury has been inflicted directly by microbial products (e.g., endotoxins and exotoxins), or indirectly by host responses (e.g., cytokines and hydrolytic enzymes released by polymorphonuclear leukocytes). Despite the extraordinary recent advances that have occurred in therapeutics for infectious diseases, a number of basic principles should be followed to prescribe antimicrobials and vaccines is an optimal manner.

Tetracyclines General Statement: Uses

Tetracyclines are used principally in the treatment of infections caused by susceptible Rickettsia, Chlamydia, Mycoplasma, and a variety of uncommon gram-negative and gram-positive bacteria.

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Chloramphenicol should be used only for the treatment of serious infections caused by susceptible bacteria or Rickettsia when potentially less toxic drugs are ineffective or contraindicated. The drug must not be used for the treatment of trivial infections, as a prophylactic agent to prevent bacterial infections, or when it is not indicated as in the treatment of colds, influenza, or throat infections.

Imipenem and Cilastatin

Imipenem and cilastatin sodium is a fixed combination of imipenem monohydrate (a semisynthetic carbapenem b-lactam antibiotic) and cilastatin sodium, 1, 35 which prevents renal metabolism of imipenem by dehydropeptidase I (DHP I).


Like other parenteral third generation cephalosporins (cefoperazone, cefotaxime, ceftizoxime, ceftriaxone), ceftazidime is less active than first and second generation cephalosporins against some gram-positive bacteria (e.g., staphylococci) and generally should not be used in the treatment of infections caused by these organisms when a penicillin or first or second generation cephalosporin could be used.

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Tetracycline [Sumycin 250mg, 500mg]. Tetracycline Hydrochloride. Tetracycline Phosphate Complex.

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Amoxicillin has been reported to be more active in vitro than ampicillin against Enterococcus faecalis, Helicobacter pylori, and Salmonella spp., but less active against Shigella spp. Amoxicillin is inactivated by beta lactamases and complete cross-resistance has been reported between amoxicillin and ampicillin.

Treatment for melioidosis

Answer: Melioidosis is an infectious disease caused by a bacterium called Pseudomonas pseudomallei. The disease has several forms depending on the location of the infection, each varying in severity. Melioidosis is most frequently reported in Southeast Asia. The bacterium that causes the disease is found in the soil, rice paddies, and stagnant waters of the area.