Tags: Griseofulvin

Dermatophytes

Dermatophytes are molds that infect keratinized tissues including skin, hair, and nails. Whereas 40 dermatophyte species are known to infect humans, only about 15 of these are common causes of disease. These organisms belong to three genera, Microsporum, Trichophyton, and Epidermophyton. Because these fungi have such similar infectivity, morphology, and pathogenicity, they are often categorized according to the clinical syndrome and the preferred anatomic site with which they are associated, such as tinea capitis, tinea pedis, etc.

Griseofulvin 250 mg Tablets (Grifulvin)

Griseofulvin is an antifungal antibiotic derived from a number of Penicillium species. It was the first oral drug for treatment of dermatophytosis. Griseofulvin is a fungistatic drug which binds to microtubular proteins and inhibits fungal cell mitosis. It also acts as an inhibitor of nucleic acid synthesis.

Management of Tinea Unguium

Fungal infection of the nails (onychomycosis) may be caused by a number of dermatophytes as well as by a number of other moulds and Candida species. There is wide geographical and racial variation in the causative agents, but in the UK 85-90% of nail infections are due to dermatophytes and about 5% are due to non-dermatophyte moulds.

Management of Tinea Cruris

The dermatophytes most often encountered in tinea cruris are E. floccosum and T. rubrum. Maceration and occlusion of the skin in the groin give rise to warm moist conditions that favour the development of the infection. Tinea cruris is a common form of dermatophytosis.

Management of Tinea Corporis

Tinea corporis is caused by E. floccosum and many species of Trichophyton and Microsporum. Infection with anthropophilic species, such as E. floccosum or T. rubrum often follows autoinoculation from another infected body site, such as the feet. Tinea corporis caused by T. tonsurans is sometimes seen in children with tinea capitis and their close contacts. Tinea corporis commonly occurs following contact with infected household pets or farm animals, but occasional cases result from contact with wild mammals or contaminated soil.

Management of Tinea Capitis

The condition is worldwide in distribution, but is most prevalent in Africa, Asia and southern and eastern Europe, where it is the most common form of dermatophytosis. Improved standards of hygiene and prompt eradication of sporadic infection have led to a marked decline in the incidence of tinea capitis in North America and western Europe.

Buy Cheap Griseofulvin (Grifulvin) No Prescription 250mg

Griseofulvin was originally isolated in 1939 as a natural product of Penicillium griseofulvum. It interferes with fungal microtubule formation, disrupting the cell’s mitotic spindle formation and arresting the metaphase of cell division. Griseofulvin is a fungistatic compound and is active against Trichophyton, Microsporon, and Epidermophyton species.

Order Generic Grifulvin (Griseofulvin) No Prescription 250mg

Headache is the most common adverse effect of griseofulvin. It occurs in about 50% of patients and can be severe. Drowsiness, dizziness, fatigue, confusion, depression, irritability, and insomnia have also been observed. Impaired co-ordination and unsteadiness while walking have been reported in some cases when there was confusion.

Buy Fluconazole (Diflucan) Without Prescription 50/100/150/200mg

Dizziness, headache, and seizures were seen in 2-5% of 232 patients with severe systemic fungal infections taking fluconazole. In the same group there were three cases each of delirium and dysesthesia (1.3%).