Tags: Cefixime

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Cefixime is authorised in the world under the following brand names: Cefixoral, Cefspan, Cephoral, CFIX, Oroken, Suprax, Unixime.

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Neisseria Meningitidis

N meningitidis is found only in humans and is a member of the normal oropharyngeal flora in 5-15% of healthy adults and children. In crowded or closed populations such as in boarding schools or military camps, higher carriage rates are observed.

Streptococcus Pyogenes

Streptococcus pyogenes is a human pathogen without an animal reservoir. Group A streptococci (GAS) cause most streptococcal disease, but other groups are important pathogens in some settings (Box 1). Group A streptococcal infections have the highest incidence in children younger than age 10. The asymptomatic prevalence is also higher (15-20%) in children, compared with that in adults (<5%).

Specific Causes Of Acute Community-Acquired Pneumonia

Great overlap occurs among the clinical manifestations of the pathogens associated with acute community-acquired pneumonia. However, constellations of symptoms, signs, and laboratory findings serve to narrow the possibilities. By developing an ability to focus on a few pathogens or to identify a specific pathogen, clinicians can better predict the clinical course of pneumonia and can narrow antibiotic coverage. Pathogenic strains of S. pneumoniae have a thick capsule that prevents PMN binding and that blocks phagocytosis.

Anti-Infective Agent Dosing

The characteristics that need to be considered when administering antibiotics include absorption (when dealing with oral antibiotics), volume of distribution, metabolism, and excretion. These factors determine the dose of each drug and the time interval of administration. To effectively clear a bacterial infection, serum levels of the antibiotic need to be maintained above the minimum inhibitory concentration for a significant period. For each pathogen, the minimum inhibitory concentration is determined by serially diluting the antibiotic into liquid medium containing 104 bacteria per millihter.

Specific Anti-Infective Agents

Clinicians should be familiar with the general classes of antibiotics, their mechanisms of action, and their major toxicities. The differences between the specific antibiotics in each class can be subtle, often requiring the expertise of an infectious disease specialist to design the optimal anti-infective regimen. The general internist or physician-in-training should not attempt to memorize all the facts outlined here, but rather should read the pages that follow as an overview of anti-infectives. The chemistry, mechanisms of action, major toxicities, spectrum of activity, treatment indications, pharmacokinetics, dosing regimens, and cost are reviewed.

Urinary Tract Infections and Prostatitis

A urinary tract infection is defined as the presence of microorganisms in the urine that cannot be accounted for by contamination. The organisms have the potential to invade the tissues of the urinary tract and adjacent structures.

Syphilis: Primary, Secondary, Latent, Tertiary

Primary syphilis is characterized by the appearance of a chancre on cutaneous or mucocutaneous tissue. Chancres persist only for 1 to 8 weeks before spontaneously disappearing.

Respiratory Tract Infections, Upper

The goals of treatment include reduction in signs and symptoms, eradication of infection, and prevention of complications. Avoidance of unnecessary antibiotic use is another goal in view of S. pneumonia. dClindamycin is only recommended in cases of documented S. pneumoniae. It is not effective against H. influenzae or M. catarrhalis.

Respiratory Tract Infections, Lower

Bronchitis, bronchiolitis, pneumonia clinical presentation and treatment.

Bacterial Infections

Enterotoxigenic (cholera-like) Diarrhea. Escherichia coli. Pseudomembranous Colitis (Clostridium difficile).

Dosage forms of Cefixime:
Suprax 100 mg/5ml Suspension Suprax 400 mg Tablet Suprax 20 mg/ml Suspension

Synonyms of Cefixime:

Cefixim, Cefixima [Spanish], Cefixime Anhydrous, Cefiximum [Latin]

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Therapeutic classes of Cefixime:

Anti-Bacterial Agents, Cephalosporins

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