Tags: Amikin

Anaerobic & Necrotizing Infections

Gangrene is local death of soft tissues due to disease or injury and is associated with loss of blood supply. Anaerobic and necrotizing infections may be associated with gas.

Pulmonary Infections

Acute pneumonia is a potentially life-threatening illness requiring rapid diagnosis and treatment. A delay in antibiotic treatment increases the risk of a fatal outcome. Annually, 2 to 3 million cases of pneumonia are reported in the United States.

Specific Anti-Infective Agents

Clinicians should be familiar with the general classes of antibiotics, their mechanisms of action, and their major toxicities. The differences between the specific antibiotics in each class can be subtle, often requiring the expertise of an infectious disease specialist to design the optimal anti-infective regimen. The general internist or physician-in-training should not attempt to memorize all the facts outlined here, but rather should read the pages that follow as an overview of anti-infectives. The chemistry, mechanisms of action, major toxicities, spectrum of activity, treatment indications, pharmacokinetics, dosing regimens, and cost are reviewed.

Antimicrobial therapy: general principles

A wide variety of antimicrobial agents is available to treat established infections caused by bacteria, fungi, viruses, or parasites. This section will cover the general principles of antimicrobial therapy and will also include illustrative clinical problems to emphasize proper decision-making in using antimicrobials.


Amikacin is a semisynthetic aminoglycoside antibiotic derived from kanamycin and is used similarly to gentamicin in the treatment of severe Gram-negative and other infections. It is given as the sulfate, and is generally reserved for the treatment of severe infections caused by susceptible bacteria that are resistant to gentamicin and tobramycin.