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Buy No Prescription Lamprene (Clofazimine) 50mg

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Clofazimine is authorised in the world under the following brand names: Lampren, Lamprene.

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Clofazimine: Side Effects

See also Antituberculosis drugs

Clofazimine is weakly bactericidal against Mycobacterium leprae. It is active in chronic skin ulcers (Buruli ulcer) and partly against Mycobacterium avium intracellulare. The usual adult dosage is 50-100 mg/day. At higher doses, its anti-inflammatory effect seems to prevent the development of acute reactions, such as erythema nodosum leprosum.

Clofazimine is a strongly lipophilic dye and accumulates in tissues, especially fat, bile, macrophages, the reticuloendothelial system, and skin. This is the basis of adverse reactions, including skin discoloration. Lymphedema, diminished sweating, and reduced tearing have been observed.

Observational studies

In 84 patients with leprosy who took clofazimine, the most common adverse effect was a dark red skin pigmentation of varying intensity, which appeared within 10 weeks of the start of therapy. The intensity of the colour was proportional to the density of the infiltration. There was ichthyosis in 56 patients. Adverse effects such as anorexia, diarrhea, lymph gland enlargement, liver enlargement, corneal drying, and loss of weight were self-correcting, but nine patients had severe gastrointestinal effects (severe abdominal pain, vomiting, and diarrhea).

Organs and Systems


Clofazimine crystals were observed in macrophages in the respiratory alveoli of a patient with AIDS; this is considered harmless.

Nervous system

Intraneural deposition of a ceroid-like pigment has been seen after treatment of lepromatous leprosy with clofazimine. This pigment does not affect the healing process. Treatment can be continued, provided that the dose is not too high.

Sensory systems

In 76 patients taking multidrug therapy, including clofazimine, for at least 6 months, 46% had conjunctival deposition, 53% had deposition in the cornea, and crystals were found in the tears of 32%. Conjunctival pigmentation has been reported, as well as reversible linear brownish corneal streaks. Two cases of macular pigmentation have also been described.


Nausea, vomiting, diarrhea, abdominal pain, and anorexia have been reported with clofazimine.

Clofazimine can accumulate and precipitate in tissues, such as the wall of the small bowel, after prolonged administration. Enteropathy can develop if crystals are stored in the lamina propria of the jejunal mucosa and the mesenteric lymph nodes. These effects depend on the dosage and duration of therapy. When this complication is suspected jejunal biopsy is indicated. At laparotomy, all organs can have an orange-yellow color. On drug withdrawal, the enteropathy progressively improves. Recognized for the first time in 1967, only 14 cases of this complication have so far appeared in the English-language literature. Acute or chronic abdominal pain was the main symptom. In most patients, the diagnosis was made after exploratory laparotomy. Barium meal follow-through or CT scanning of the abdomen showed mucosal thickening in the small intestine. Mesenteric lymph node enlargement was present in the index case. Characteristic eosinophilic clofazimine crystals were demonstrated in the histiocytes of all patients except three. The authors proposed the term "clofazimine-induced crystal-storage histiocytosis" to emphasize causes other than B cell neoplasms for crystal-storage histiocytosis. Awareness of this complication of clofazimine can avoid unnecessary surgical exploration.


Clofazimine can inhibit the liver damage that is associated with lepromatous leprosy and the leprosy reaction; it has only minimal or no deleterious effects on liver function.


Pigmentation and purple skin discoloration are the most frequent adverse effects of clofazimine. It is therefore unacceptable to most light-skinned patients.

Ichthyosis is very frequent at dosages of clofazimine over 100 mg/day.


Nail changes, such as brown discoloration of the nail plate and onycholysis, have been described in patients taking high doses (300 mg/day) of clofazimine. Clofazimine crystals were demonstrated in the nails and nail beds.

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Dosage forms of Clofazimine:
Clofazimine powder

Synonyms of Clofazimine:

Chlofazimine, Clofazimina [INN-Spanish], Clofaziminum [INN-Latin]

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Therapeutic classes of Clofazimine:

Antimycobacterials, Coloring Agents, Dyes, Leprostatic Agents


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