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Buy Avelox (Moxifloxacin) Without Prescription

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Moxifloxacin is authorised in the world under the following brand names: Avelox, Avelox I.V., Vigamox.

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Moxifloxacin (Bayer Schering-Plough's Avelox) is a fluoroquinolone used for the treatment of RTIs. In December 1999, the FDA approved the oral formulation of moxifloxacin for the treatment of community-acquired pneumonia and other respiratory diseases; in December 2001, the agency approved the parenteral formulation of the agent for the same indications. In Germany, oral moxifloxacin received regulatory approval in September 1999 for the treatment of community-acquired infections, including community-acquired pneumonia; the parenteral formulation was approved in May 2002.

Oral moxifloxacin was recently launched in France, Spain, and Italy. In Japan, moxifloxacin is in Phase III and Phase I trials for the oral and IV formulations, respectively. In September 2003, Schering-Plough and Bayer announced a strategic alliance in which Schering-Plough acquired exclusive rights to market, sell, and distribute moxifloxacin (as well as Bayer's other antibiotic, ciprofloxacin) in the United States. This agent is expected to retain patent protection through 2014 in the United States and through 2009 in Europe and Japan.

Moxifloxacin displays excellent activity against a broad spectrum of bacteria, including penicillin- and/or macrolide-resistant S. pneumoniae. It is highly active against the following pathogens:

  • Common RTI pathogens such as S. pneumoniae, H. influenzae, and M. catarrhalis.
  • RTI pathogens with reduced susceptibility to conventional agents, such as penicillin- and macrolide-resistant strains of S. pneumoniae.
  • Unusual community RTI pathogens such as S. aureus and K. pneumoniae.
  • Atypical microorganisms, such as Mycoplasma, Legionella, and Chlamydia.

Moxifloxacin offers superior activity against S. pneumoniae, compared with current quinolones (e.g., ciprofloxacin, levofloxacin), and is highly effective in treating other respiratory pathogens.

Several multinational clinical trials have compared the efficacy of oral moxifloxacin with that of either amoxicillin or clarithromycin in the treatment of community-acquired pneumonia. The studies found that moxifloxacin's overall clinical success rate (92%) and bacterial eradication rate (94%) were equivalent or superior to clarithromycin and amoxicillin rates. Adverse effects associated with moxifloxacin were primarily GI-related (e.g., nausea and diarrhea) and were mild to moderate in severity. Other adverse events reported included rash and dizziness. In postmarketing surveillance of moxifloxacin, less than 5% of patients experienced an adverse event and less than 2% withdrew as a result of a severe adverse event.

Additional advantages of moxifloxacin are its high bioavailability and the bioequivalence of the oral and parenteral forms, which require no dose adjustment when stepping down from IV to oral therapy. In a randomized, open-label Phase II study, 628 hospitalized patients with community-acquired pneumonia received sequential IV-to-oral therapy with moxifloxacin or amoxicillin/clavulanate, with or without clarithromycin, for 7-14 days. Clinical cure at five to seven days post-therapy was 93% for moxifloxacin compared with 85% for the comparator group.

Moxifloxacin's long half-life allows once-daily dosing, and the drug has limited drug-drug interactions. Moxifloxacin is not associated with phototoxicity, but like other fluoroquinolones, it has been shown to alter the QT interval.

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Dosage forms of Moxifloxacin:
Avelox abc pack 400 mg tablet Avelox 400 mg tablet Vigamox 0.5% eye drops Vigamox 0.5% Solution 3ml Bottle
Avelox iv 400 mg/250 ml      

Synonyms of Moxifloxacin:

BAY 12-8039, Moxifloxacin, Moxifloxacin HCl, Moxifloxacin Hydrochloride

How can i get Moxifloxacin online over the counter?

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Therapeutic classes of Moxifloxacin:

Anti-Bacterial Agents, Anti-Infective Agents, Quinolones


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