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Order No Prescription Levaquin (Levofloxacin) 250/500/750mg

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Levofloxacin is authorised in the world under the following brand names: Cravit, Cravit Ophthalmic, Elequine, Floxel, Iquix, Leroxacin, Lesacin, Levaquin, Levokacin, Levox, Levoxacin, Mosardal, Nofaxin, Quixin, Reskuin, Tavanic, Volequin.

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Levofloxacin (Johnson & Johnson’s Levaquin, Sanofi-Aventis’ Tavanic, Daiichi’s Cravit) (Figure 12) is a widely successful fluoroquinolone approved for the treatment of community-acquired pneumonia and several other bacterial infections (e.g., bronchitis, urinary tract infection, skin infections). In the United States, the agent is a leading antibiotic for community-acquired pneumonia owing to its high bioavailability, broad-spectrum activity, tolerability, and once-daily dosing. Levofloxacin was first launched in Japan in 1993 and has been widely available since 1998. Most recently, a new, high-dose formulation (750 mg) has been approved that provides patients an abbreviated five-day treatment course for community-acquired pneumonia. The agent is expected to lose patent protection in the United States and Japan in 2010 and in Europe in 2011. The drug is available in oral and IV formulations.

Levofloxacin is the levo enantiomer of ofloxacin. The agent’s mechanism of action involves inhibition of bacterial topoisomerase IV and DNA gyrase, which are enzymes required for DNA replication, transcription, repair, and recombination. Levofloxacin has in vitro activity against a wide range of gram-negative and gram-positive microorganisms.

Levofloxacin’s efficacy in adult inpatients and outpatients with community-acquired pneumonia was evaluated in two pivotal Phase III clinical studies. In the first study, 590 patients were treated with levofloxacin (500 mg) once daily orally or intravenously for 7 to 14 days or with the cephalosporin ceftriaxone (1-2 grams), administered intravenously once or twice daily, followed by the cephalosporin cefuroxime axetil (500 mg) administered orally twice daily for a total of 7 to 14 days (Ortho-McNeil, 2004). Patients assigned to treatment with the cephalosporins were allowed to receive erythromycin (or doxycycline if intolerant of erythromycin) if an infection due to atypical pathogens was suspected or proven. Clinical success (defined as the percentage of patients cured or improved at 5 to 7 days post-therapy) with levofloxacin was superior (95%) to success in the control group (83%). In a second, noncomparative study, 264 patients were treated with 500 mg levofloxacin orally or intravenously once daily for 7 to 14 days; the clinical success rate of evaluable patients in this study was 93%.

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Dosage forms of Levofloxacin:
Levaquin i.v. 25 mg/ml vial Quixin 0.5% Solution Quixin 0.5% eye drops Levaquin 250 mg tablet
Iquix 1.5% eye drops Levaquin 500 mg tablet Levaquin 750 mg leva-pak tablet Levaquin 750 mg tablet
Levofloxacin hemihydr 100% powder Iquix 1.5% Solution 5ml Bottle Levaquin 500 mg/100 ml d5w  

Synonyms of Levofloxacin:

L-Ofloxacin, Levofloxacin

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Therapeutic classes of Levofloxacin:

Anti-Bacterial Agents, Anti-Infective Agents, Urinary, Nucleic Acid Synthesis Inhibitors, Quinolones


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